Evidence map›Paper›PMID 26091520›Full record

ArticlePloS one2015

Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk.

Ganna Chornokur, Hui-Yi Lin, Jonathan P Tyrer, Kate Lawrenson, Joe Dennis, Ernest K Amankwah, Xiaotao Qu, Ya-Yu Tsai, Heather S L Jim, Zhihua Chen and 151 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
94.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 906 citations in OpenAlex.

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  15. Germline Mutations in Triple-Negative Breast Cancer.Breast care (Basel, Switzerland) · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

161 authors at 20 institutions in 16 countries.

Ganna ChornokurDivision of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.
Hui-Yi LinDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America.
Jonathan P TyrerDepartment of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Kate LawrensonDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America.
Joe DennisDepartment of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Ernest K AmankwahDivision of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America; Clinical and Translational Research Organization, All Children's Hospital Johns Hopkins Medicine, St Petersburg, Florida, United States of America.
Xiaotao QuDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America.
Ya-Yu TsaiDivision of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.
Heather S L JimDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida, United States of America.
Zhihua ChenDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America.
Ann Y ChenDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America.
Jennifer Permuth-WeyDivision of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.
Katja K H AbenRadboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands; Comprehensive Cancer Center The Netherlands, Nijmegen, The Netherlands.
Hoda Anton-CulverGenetic Epidemiology Research Institute, Center for Cancer Genetics Research and Prevention, University of California Irvine, Irvine, California, United States of America.
Natalia AntonenkovaN.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus.
Fiona BruinsmaCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Elisa V BanderaCancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America.
Yukie T BeanDepartment of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon, United States of America; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America.
Matthias W BeckmannDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University, Erlangen-Nuremberg Comprehensive Cancer Center, Erlangen EMN, Erlangen, Germany.
Maria BisognaGynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.
Line BjorgeDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway; Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Natalia BogdanovaRadiation Oncology Research Unit, Hannover Medical School, Hannover, Germany.
Louise A BrintonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America.
Angela Brooks-WilsonCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada.
Clareann H BunkerDepartment of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America.
Ralf ButzowDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland; Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland.
Ian G CampbellCancer Genetics Laboratory Research Division, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Australia; Department of Pathology, the University of Melbourne, Parkville, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
Karen CartyDepartment of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, United Kingdom; The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom.
Jenny Chang-ClaudeGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.
Linda S CookDivision of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, United States of America.
Daniel W CramerObstetrics and Gynecology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Julie M CunninghamDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America.
Cezary CybulskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Agnieszka Dansonka-MieszkowskaDepartment of Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Andreas du BoisDepartment of Gynaecology and Gynaecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany; Department of Gynaecology and Gynaecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany.
Evelyn DespierreDivision of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Ed DicksDepartment of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Jennifer A DohertyDepartment of Epidemiology, The Geisel School of Medicine Hanover, New Hampshire, United States of America; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, United States of America.
Thilo DörkGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Matthias DürstDepartment of Gynecology, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom; Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America.
Diana M EcclesFaculty of Medicine, University of Southampton, Southampton, United Kingdom.
Robert P EdwardsOvarian Cancer Center of Excellence, Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America.
Arif B EkiciInstitute of Human Genetics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany.
Peter A FaschingDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University, Erlangen-Nuremberg Comprehensive Cancer Center, Erlangen EMN, Erlangen, Germany; University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, California, United States of America.
Brooke L FridleyBiostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, Kansas, United States of America.
Yu-Tang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Aleksandra Gentry-MaharajWomen's Cancer, Institute for Women's Health, University College London, London, United Kingdom.
Graham G GilesCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia; Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Rosalind GlasspoolThe Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom.
Marc T GoodmanCancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America; Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Jacek GronwaldInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Patricia HarringtonDepartment of Oncology, The Centre for Cancer Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom.
Philipp HarterDepartment of Gynaecology and Gynaecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany; Department of Gynaecology and Gynaecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany.
Alexander HeinDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University, Erlangen-Nuremberg Comprehensive Cancer Center, Erlangen EMN, Erlangen, Germany.
Florian HeitzDepartment of Gynaecology and Gynaecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany; Department of Gynaecology and Gynaecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany.
Michelle A T HildebrandtDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Peter HillemannsGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Claus K HogdallThe Juliane Marie Centre, Department of Gynecology, Righospitalet, University of Copenhagen, Copenhagen, Denmark.
Estrid HogdallMolecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark; Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Satoyo HosonoDepartment of Preventive Medicine, Kyushu University Faculty of Medical Science, Nagoya, Aichi, Japan.
Anna JakubowskaInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Allan JensenDepartment of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Bu-Tian JiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America.
Beth Y KarlanWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Linda E KelemenDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, United States of America.
Mellissa KellarDepartment of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon, United States of America; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America.
Lambertus A KiemeneyRadboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Camilla KrakstadDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway; Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Susanne K KjaerDepartment of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Jolanta KupryjanczykDepartment of Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Diether LambrechtsVesalius Research Center, VIB, Leuven, Belgium; Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Belgium.
Sandrina LambrechtsDivision of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Nhu D LeCancer Control Research, BC Cancer Agency, Vancouver, Canada.
Alice W LeeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America.
Shashi LeleDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America.
Arto LeminenDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland.
Jenny LesterWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Douglas A LevineGynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.
Dong LiangCollege of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, United States of America.
Boon Kiong LimDepartment of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia.
Jolanta LissowskaDepartment of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Karen LuDepartment of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Jan LubinskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Lene LundvallThe Juliane Marie Centre, Department of Gynecology, Righospitalet, University of Copenhagen, Copenhagen, Denmark.
Leon F A G MassugerDepartment of Gynaecology, Radboud University Medical Center, Nijmegen, The Netherlands.
Keitaro MatsuoDepartment of Preventive Medicine, Kyushu University Faculty of Medical Science, Nagoya, Aichi, Japan.
Valerie McGuireDepartment of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, United States of America.
John R McLaughlinPublic Health Ontario, Toronto, Canada.
Iain McNeishInstitute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer research Centre, Beatson Institute for Cancer Research, Glasgow, UK.
Usha MenonWomen's Cancer, Institute for Women's Health, University College London, London, United Kingdom.
Roger L MilneCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Francesmary ModugnoDepartment of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America; Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
Kirsten B MoysichDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America.
Roberta B NessThe University of Texas School of Public Health, Houston, Texas, United States of America.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland.
Ursula EilberGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.
Kunle OdunsiDepartment of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, United States of America.
Sara H OlsonDepartment of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.
Irene OrlowDepartment of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.
Sandra OrsulicWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Rachel Palmieri WeberDepartment of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, United States of America.
James PaulThe Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom.
Celeste L PearceDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America; Department of Epidemiology, University of Michigan School of Public Health,Ann Arbor, Michigan, United States of America.
Tanja PejovicDepartment of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon, United States of America; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America.
Liisa M PelttariDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland.
Malcolm C PikeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America; Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.
Elizabeth M PooleChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.
Harvey A RischDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, United States of America.
Barry RosenDepartment of Gynecology-Oncology, Princess Margaret Hospital, and Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Mary Anne RossingProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, United States of America.
Joseph H RothsteinDepartment of Health Research and Policy- Epidemiology, Stanford University School of Medicine, Stanford, California, United States of America.
Anja RudolphGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.
Ingo B RunnebaumDepartment of Gynecology, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
Iwona K RzepeckaDepartment of Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Helga B SalvesenDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway; Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Eva SchernhammerChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.
Ira SchwaabInstitut für Humangenetik, Wiesbaden, Germany.
Xiao-Ou ShuEpidemiology Center and Vanderbilt, Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Yurii B ShvetsovCancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, United States of America.
Nadeem SiddiquiDepartment of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, United Kingdom.
Weiva SiehDepartment of Health Research and Policy- Epidemiology, Stanford University School of Medicine, Stanford, California, United States of America.
Honglin SongDepartment of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Melissa C SoutheyDepartment of Pathology, the University of Melbourne, Parkville, Australia.
Beata SpiewankiewiczDepartment of Gynecologic Oncology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Lara SuchestonDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America.
Soo-Hwang TeoCancer Research Initiatives Foundation, Sime Darby Medical Center, Subang Jaya, Malaysia; University Malaya Cancer Research Institute, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Maylaysia.
Kathryn L TerryObstetrics and Gynecology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Pamela J ThompsonCancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America; Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Lotte ThomsenDepartment of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Ingvild L TangenDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway; Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Shelley S TworogerObstetrics and Gynecology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.
Anne M van AltenaDepartment of Gynaecology, Radboud University Medical Center, Nijmegen, The Netherlands.
Robert A VierkantDepartment of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America.
Ignace VergoteDivision of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Christine S WalshWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Shan Wang-GohrkeGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America.
Alice S WhittemoreDepartment of Health Research and Policy- Epidemiology, Stanford University School of Medicine, Stanford, California, United States of America.
Kristine G WicklundProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, United States of America.
Lynne R WilkensCancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, United States of America.
Anna H WuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America.
Xifeng WuDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Yin-Ling WooDepartment of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia.
Hannah YangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America.
Wei ZhengVanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Argyrios ZiogasGenetic Epidemiology Research Institute, Center for Cancer Genetics Research and Prevention, University of California Irvine, Irvine, California, United States of America.
Hanis N HasmadCancer Research Initiatives Foundation, Sime Darby Medical Center, Subang Jaya, Malaysia.
Andrew BerchuckDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, United States of America.
Georgia Chenevix-Trench
AOCS management group
Edwin S IversenDepartment of Statistics, Duke University, Durham, North Carolina, United States of America.
Joellen M SchildkrautCancer Prevention, Detection & Control Research Program, Duke Cancer Institute, Durham, North Carolina, United States of America.
Susan J RamusDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America.
Ellen L GoodeDepartment of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, United States of America.
Alvaro N A MonteiroDivision of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.
Simon A GaytherDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America.
Steven A NarodWomen's College Research Institute, University of Toronto, Toronto, Ontario, Canada.
Paul D P PharoahDepartment of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Thomas A SellersDivision of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.
Catherine M PhelanDivision of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.
Moffitt Cancer Center · USUniversity of Southern California · USCedars-Sinai Medical Center · USUniversity of Cambridge · GBBrigham and Women's Hospital · USThe Maria Sklodowska-Curie National Research Institute of Oncology · PLUniversity of Copenhagen · DKGerman Cancer Research Center · DEHaukeland University Hospital · NOInternational Hereditary Cancer Center · PLMemorial Sloan Kettering Cancer Center · USNational Cancer Institute · USRadboud University Nijmegen · NLRoswell Park Comprehensive Cancer Center · USUniversity of Helsinki · FIBeatson West of Scotland Cancer Centre · GBHelios Dr. Horst Schmidt Kliniken Wiesbaden · DEKU Leuven · BEMedizinische Hochschule Hannover · DEOregon Health & Science University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
Hormone-Related CancersZIACP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$103.5M
TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Chang S Chan · 1997 to 2026
$94.5M
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI Zhenkun Lou · 2009 to 2026
$37.0M
Risk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3M
Northern California Cooperative Family Registry for Breast CancerU01CA069417 · NCI · NORTHERN CALIFORNIA CANCER CENTER · PI JOHN, ESTHER M. · 1995 to 2010
$22.4M
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6 · The paper itself

Abstract

backgroundDefective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberrant expression of key regulatory cancer genes. As DNA damage and uncontrolled proliferation are hallmarks of cancer, including epithelial ovarian cancer (EOC), we hypothesized that inherited variation in the cellular transport genes contributes to EOC risk.

methodsIn total, DNA samples were obtained from 14,525 case subjects with invasive EOC and from 23,447 controls from 43 sites in the Ovarian Cancer Association Consortium (OCAC). Two hundred seventy nine SNPs, representing 131 genes, were genotyped using an Illumina Infinium iSelect BeadChip as part of the Collaborative Oncological Gene-environment Study (COGS). SNP analyses were conducted using unconditional logistic regression under a log-additive model, and the FDR q<0.2 was applied to adjust for multiple comparisons.

resultsThe most significant evidence of an association for all invasive cancers combined and for the serous subtype was observed for SNP rs17216603 in the iron transporter gene HEPH (invasive: OR = 0.85, P = 0.00026; serous: OR = 0.81, P = 0.00020); this SNP was also associated with the borderline/low malignant potential (LMP) tumors (P = 0.021). Other genes significantly associated with EOC histological subtypes (p<0.05) included the UGT1A (endometrioid), SLC25A45 (mucinous), SLC39A11 (low malignant potential), and SERPINA7 (clear cell carcinoma). In addition, 1785 SNPs in six genes (HEPH, MGST1, SERPINA, SLC25A45, SLC39A11 and UGT1A) were imputed from the 1000 Genomes Project and examined for association with INV EOC in white-European subjects. The most significant imputed SNP was rs117729793 in SLC39A11 (per allele, OR = 2.55, 95% CI = 1.5-4.35, p = 5.66x10-4).

conclusionThese results, generated on a large cohort of women, revealed associations between inherited cellular transport gene variants and risk of EOC histologic subtypes.

Indexed as

Genetic VariationRiskAllelesAsianBiological TransportBlack or African AmericanCarcinoma, Ovarian EpithelialCarrier ProteinsCase-Control StudiesFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansNeoplasms, Glandular and EpithelialOdds RatioOvarian NeoplasmsCarrier Proteins

Identifiers

PMID26091520
PMCPMC4474865
OpenAlexW1780088415

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