ArticleThe journal of trauma and acute care surgery2015
New low-volume resuscitation solutions containing PEG-20k.
Article in The journal of trauma and acute care surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Biosynthetic blood surrogates: Current status and future opportunities.Bioengineering & translational medicine · 2025Review
- Metabolic Tissue Swelling and Local Microcirculation in Splanchnic Artery Occlusion Shock: Implications for Critical Illness.The Journal of pharmacology and experimental therapeutics · 2024Article
- ENGINEERED INTRAVENOUS THERAPIES FOR TRAUMA.Current opinion in biomedical engineering · 2023Article
- Intravenous Polyethylene Glycol Alleviates Intestinal Ischemia-Reperfusion Injury in a Rodent Model.International journal of molecular sciences · 2023Article
- Assessment of machine perfusion conditions for the donation after circulatory death heart preservation.Artificial organs · 2022Article
- Pathophysiology of Hemorrhage as It Relates to the Warfighter.Physiology (Bethesda, Md.) · 2022Review
- Combined Therapy With Polyethylene Glycol-20k and MCC950 Preserves Post-Resuscitated Myocardial Function in a Rat Model of Cardiac Arrest and Cardiopulmonary Resuscitation.Journal of the American Heart Association · 2021Article
- Effects of Polyethylene Glycol-20k on Coronary Perfusion Pressure and Postresuscitation Myocardial and Cerebral Function in a Rat Model of Cardiac Arrest.Journal of the American Heart Association · 2020Article
- Effects of a novel low volume resuscitation solutions on coagulation and platelet function.PloS one · 2019Article
- Social, economic, and policy implications of organ preservation advances.Current opinion in organ transplantation · 2018Review
- Physician Awareness of Immune Responses to Polyethylene Glycol-Drug Conjugates.Clinical and translational science · 2018Article
- Thromboelastographic analysis of novel polyethylene glycol based low volume resuscitation solutions.PloS one · 2018Article
- The promise of organ and tissue preservation to transform medicine.Nature biotechnology · 2017Review
- Low-volume resuscitation using polyethylene glycol-20k in a preclinical porcine model of hemorrhagic shock.The journal of trauma and acute care surgery · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundHypovolemic shock reduces oxygen delivery and compromises energy-dependent cell volume control. Consequent cell swelling compromises microcirculatory flow, which reduces oxygen exchange further. The importance of this mechanism is highlighted by the effectiveness of cell impermeants in low-volume resuscitation (LVR) solutions in acute studies. The objectives of this study were to assess impermeants in survival models and to compare them with commonly used crystalloid solutions.
methodsAdult rats were hemorrhaged to a pressure of 30 mm Hg to 35 mm Hg, held there until the plasma lactate reached 10 mM, and given an LVR solution (5-10% blood volume) with saline alone (control) and saline with various concentrations of polyethylene glycol-20k (PEG-20k), Hextend, or albumin. When lactate again reached 10 mM following LVR, full resuscitation was started with crystalloid and red blood cells. Rats were either euthanized (acute) or allowed to recover (survival). The LVR time, which is the time from the start of the LVR solution until the start of full resuscitation, was measured as was survival and diagnostic laboratory values. In some studies, the capillary oncotic reflection coefficient was determined for PEG-20k to determine its relative impermeant and oncotic effects.
resultsPEG-20k (10%) significantly increased LVR times relative to saline (eightfold), Hextend, and albumin. Lower amounts of PEG-20k (5%) were also effective but less so than 10% doses. PEG-20k maintained normal arterial pressure during the low-volume state. Survival of a 180-minute LVR time challenge was 0% in saline controls and 100% in rats given PEG-20k as the LVR solution. Surviving rats had normal laboratory values 24 hours later. PEG-20k had an oncotic reflection coefficient of 0.65, which indicates that the molecule is a hybrid cell impermeant with significant oncotic properties.
conclusionPEG-20k-based LVR solutions are highly effective for inducing tolerance to the low-volume state and for improving survival.
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