Evidence map›Paper›PMID 26091202›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2015

Effect of Vitamin D3 Supplementation in Black and in White Children: A Randomized, Placebo-Controlled Trial.

Kumaravel Rajakumar, Charity G Moore, Jonathan Yabes, Flora Olabopo, Mary Ann Haralam, Diane Comer, Jaimee Bogusz, Anita Nucci, Susan Sereika, Jacqueline Dunbar-Jacob and 2 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00732758 (Defining Vitamin D Insufficiency in School Age Children), which is not on this map. Cited by 24 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 4 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00732758 phase1completednot on this map

Defining Vitamin D Insufficiency in School Age Children: A Randomized Placebo Controlled Trial of Vitamin D3

TypeinterventionalSponsorUniversity of PittsburghRan2008 to 2011Enrolled157ConditionsHealthyArmsVitamin D3 1000 IU, Placebo Tablet
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Kumaravel RajakumarDepartment of Pediatrics (K.R., F.O., M.A.H.), and Center for Research on Health Care (C.G.M., J.Y., D.C.), University of Pittsburgh, Pittsburgh, Pennsylvania 15213; Department of Medicine (J.B., M.F.H.), Boston University School of Medicine, Boston, Massachusetts, 02118; Department of Nutrition (A.N.), Georgia State University, Atlanta, Georgia 30302; University of Pittsburgh School of Nursing (S.S., J.D.-J.), Pittsburgh, Pennsylvania 15213; and Department of Medicine (C.G.M., J.Y., D.C., S.L.G.), University of Pittsburgh, Pittsburgh 15213.
Charity G MooreDepartment of Pediatrics (K.R., F.O., M.A.H.), and Center for Research on Health Care (C.G.M., J.Y., D.C.), University of Pittsburgh, Pittsburgh, Pennsylvania 15213; Department of Medicine (J.B., M.F.H.), Boston University School of Medicine, Boston, Massachusetts, 02118; Department of Nutrition (A.N.), Georgia State University, Atlanta, Georgia 30302; University of Pittsburgh School of Nursing (S.S., J.D.-J.), Pittsburgh, Pennsylvania 15213; and Department of Medicine (C.G.M., J.Y., D.C., S.L.G.), University of Pittsburgh, Pittsburgh 15213.
Jonathan YabesDepartment of Pediatrics (K.R., F.O., M.A.H.), and Center for Research on Health Care (C.G.M., J.Y., D.C.), University of Pittsburgh, Pittsburgh, Pennsylvania 15213; Department of Medicine (J.B., M.F.H.), Boston University School of Medicine, Boston, Massachusetts, 02118; Department of Nutrition (A.N.), Georgia State University, Atlanta, Georgia 30302; University of Pittsburgh School of Nursing (S.S., J.D.-J.), Pittsburgh, Pennsylvania 15213; and Department of Medicine (C.G.M., J.Y., D.C., S.L.G.), University of Pittsburgh, Pittsburgh 15213.
Flora OlabopoDepartment of Pediatrics (K.R., F.O., M.A.H.), and Center for Research on Health Care (C.G.M., J.Y., D.C.), University of Pittsburgh, Pittsburgh, Pennsylvania 15213; Department of Medicine (J.B., M.F.H.), Boston University School of Medicine, Boston, Massachusetts, 02118; Department of Nutrition (A.N.), Georgia State University, Atlanta, Georgia 30302; University of Pittsburgh School of Nursing (S.S., J.D.-J.), Pittsburgh, Pennsylvania 15213; and Department of Medicine (C.G.M., J.Y., D.C., S.L.G.), University of Pittsburgh, Pittsburgh 15213.
Mary Ann HaralamDepartment of Pediatrics (K.R., F.O., M.A.H.), and Center for Research on Health Care (C.G.M., J.Y., D.C.), University of Pittsburgh, Pittsburgh, Pennsylvania 15213; Department of Medicine (J.B., M.F.H.), Boston University School of Medicine, Boston, Massachusetts, 02118; Department of Nutrition (A.N.), Georgia State University, Atlanta, Georgia 30302; University of Pittsburgh School of Nursing (S.S., J.D.-J.), Pittsburgh, Pennsylvania 15213; and Department of Medicine (C.G.M., J.Y., D.C., S.L.G.), University of Pittsburgh, Pittsburgh 15213.
Diane ComerDepartment of Pediatrics (K.R., F.O., M.A.H.), and Center for Research on Health Care (C.G.M., J.Y., D.C.), University of Pittsburgh, Pittsburgh, Pennsylvania 15213; Department of Medicine (J.B., M.F.H.), Boston University School of Medicine, Boston, Massachusetts, 02118; Department of Nutrition (A.N.), Georgia State University, Atlanta, Georgia 30302; University of Pittsburgh School of Nursing (S.S., J.D.-J.), Pittsburgh, Pennsylvania 15213; and Department of Medicine (C.G.M., J.Y., D.C., S.L.G.), University of Pittsburgh, Pittsburgh 15213.
Jaimee BoguszDepartment of Pediatrics (K.R., F.O., M.A.H.), and Center for Research on Health Care (C.G.M., J.Y., D.C.), University of Pittsburgh, Pittsburgh, Pennsylvania 15213; Department of Medicine (J.B., M.F.H.), Boston University School of Medicine, Boston, Massachusetts, 02118; Department of Nutrition (A.N.), Georgia State University, Atlanta, Georgia 30302; University of Pittsburgh School of Nursing (S.S., J.D.-J.), Pittsburgh, Pennsylvania 15213; and Department of Medicine (C.G.M., J.Y., D.C., S.L.G.), University of Pittsburgh, Pittsburgh 15213.
Anita NucciDepartment of Pediatrics (K.R., F.O., M.A.H.), and Center for Research on Health Care (C.G.M., J.Y., D.C.), University of Pittsburgh, Pittsburgh, Pennsylvania 15213; Department of Medicine (J.B., M.F.H.), Boston University School of Medicine, Boston, Massachusetts, 02118; Department of Nutrition (A.N.), Georgia State University, Atlanta, Georgia 30302; University of Pittsburgh School of Nursing (S.S., J.D.-J.), Pittsburgh, Pennsylvania 15213; and Department of Medicine (C.G.M., J.Y., D.C., S.L.G.), University of Pittsburgh, Pittsburgh 15213.
Susan SereikaDepartment of Pediatrics (K.R., F.O., M.A.H.), and Center for Research on Health Care (C.G.M., J.Y., D.C.), University of Pittsburgh, Pittsburgh, Pennsylvania 15213; Department of Medicine (J.B., M.F.H.), Boston University School of Medicine, Boston, Massachusetts, 02118; Department of Nutrition (A.N.), Georgia State University, Atlanta, Georgia 30302; University of Pittsburgh School of Nursing (S.S., J.D.-J.), Pittsburgh, Pennsylvania 15213; and Department of Medicine (C.G.M., J.Y., D.C., S.L.G.), University of Pittsburgh, Pittsburgh 15213.
Jacqueline Dunbar-JacobDepartment of Pediatrics (K.R., F.O., M.A.H.), and Center for Research on Health Care (C.G.M., J.Y., D.C.), University of Pittsburgh, Pittsburgh, Pennsylvania 15213; Department of Medicine (J.B., M.F.H.), Boston University School of Medicine, Boston, Massachusetts, 02118; Department of Nutrition (A.N.), Georgia State University, Atlanta, Georgia 30302; University of Pittsburgh School of Nursing (S.S., J.D.-J.), Pittsburgh, Pennsylvania 15213; and Department of Medicine (C.G.M., J.Y., D.C., S.L.G.), University of Pittsburgh, Pittsburgh 15213.
Michael F HolickDepartment of Pediatrics (K.R., F.O., M.A.H.), and Center for Research on Health Care (C.G.M., J.Y., D.C.), University of Pittsburgh, Pittsburgh, Pennsylvania 15213; Department of Medicine (J.B., M.F.H.), Boston University School of Medicine, Boston, Massachusetts, 02118; Department of Nutrition (A.N.), Georgia State University, Atlanta, Georgia 30302; University of Pittsburgh School of Nursing (S.S., J.D.-J.), Pittsburgh, Pennsylvania 15213; and Department of Medicine (C.G.M., J.Y., D.C., S.L.G.), University of Pittsburgh, Pittsburgh 15213.
Susan L GreenspanDepartment of Pediatrics (K.R., F.O., M.A.H.), and Center for Research on Health Care (C.G.M., J.Y., D.C.), University of Pittsburgh, Pittsburgh, Pennsylvania 15213; Department of Medicine (J.B., M.F.H.), Boston University School of Medicine, Boston, Massachusetts, 02118; Department of Nutrition (A.N.), Georgia State University, Atlanta, Georgia 30302; University of Pittsburgh School of Nursing (S.S., J.D.-J.), Pittsburgh, Pennsylvania 15213; and Department of Medicine (C.G.M., J.Y., D.C., S.L.G.), University of Pittsburgh, Pittsburgh 15213.
University of Pittsburgh · USBoston University · USGeorgia State University · US

Funding

UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6M
Vitamin D and Vascular Function in Obese ChildrenR01HL112985 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAJAKUMAR, KUMARAVEL · 2013 to 2017
$3.7M
Osteoporosis in Older Men and WomenK24DK062895 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GREENSPAN, SUSAN L · 2003 to 2012
$1.6M
Vitamin D Insufficiency in Pre- and Early Adolescent ChildrenK23HD052550 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAJAKUMAR, KUMARAVEL · 2007 to 2011
$667k
NCATS NIH HHS UL1 TR000005NCRR NIH HHS UL1 RR024153NHLBI NIH HHS R01 HL112985NHLBI NIH HHS R01HL112985NIA NIH HHS P30 AG024827NICHD NIH HHS K23 HD052550NICHD NIH HHS K23HD052550NIDDK NIH HHS K24 DK062895NIDDK NIH HHS K24DK062895
6 · The paper itself

Abstract

contextDosages of vitamin D necessary to prevent or treat vitamin D deficiency in children remain to be clarified.

objectiveTo determine the effects of vitamin D3 1000 IU/d on serum 25-hydroxyvitamin D [25(OH)D], PTH, and markers of bone turnover (osteocalcin and collagen type 1 cross-linked C-telopeptide) in black children and white children, and to explore whether there is a threshold level of 25(OH)D associated with maximal suppression of serum PTH concentration.

designHealthy 8- to 14-year-old Pittsburgh-area black (n = 84) and white (n = 73) children not receiving vitamin supplements, enrolled from October through March from 2008 through 2011, were randomized to vitamin D3 1000 IU or placebo daily for 6 months.

resultsThe mean baseline concentration of 25(OH)D was <20 ng/mL in both the vitamin D-supplemented group and the placebo group (19.8 ± 7.6 and 18.8 ± 6.9 ng/mL, respectively). The mean concentration was higher in the supplemented group than in the placebo group at 2 months (26.4 ± 8.1 vs 18.9 ± 8.1 ng/mL; P < .0001) and also at 6 months (26.7 ± 7.6 vs 22.4 ± 7.3; P = .003), after adjusting for baseline 25(OH)D, race, gender, pubertal status, dietary vitamin D intake, body mass index, and sunlight exposure. Increases were only significant in black children, when examined by race. The association between 25(OH)D and PTH concentrations was inverse and linear, without evidence of a plateau. Overall, vitamin D supplementation had no effect on PTH and bone turnover.

conclusionsVitamin D3 supplementation with 1000 IU/d in children with mean baseline 25(OH)D concentration <20 ng/mL effectively raised their mean 25(OH)D concentration to ≥20 ng/mL but failed to reach 30 ng/mL. Vitamin D supplementation had no effect on PTH concentrations.

Indexed as

Black or African AmericanDietary SupplementsWhite PeopleAdolescentBone DensityBone DevelopmentChildCholecalciferolDose-Response Relationship, DrugFemaleHumansMalePlacebosVitamin D DeficiencyCholecalciferolPlacebos

Identifiers

PMID26091202
PMCPMC4524986
OpenAlexW1858546658

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.