ArticlePloS one2015
Subregional Hippocampal Morphology and Psychiatric Outcome in Adolescents Who Were Born Very Preterm and at Term.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Early life stress impairs hippocampal subfield myelination.Communications biology · 2025Article
- Perinatal compromise affects development, form, and function of the hippocampus part one; clinical studies.Pediatric research · 2024Review
- Hippocampal subfield volumes are nonspecifically reduced in premature-born adults.Human brain mapping · 2020Article
- [Identification of behavioural and emotional problems in premature children in the primary care setting].Atencion primaria · 2020Article
- Hippocampal alterations and functional correlates in adolescents and young adults with congenital heart disease.Human brain mapping · 2019Article
- Trajectories of brain development in school-age children born preterm with very low birth weight.Scientific reports · 2018Article
- A latent measure explains substantial variance in white matter microstructure across the newborn human brain.Brain structure & function · 2017Article
- Heritability of the shape of subcortical brain structures in the general population.Nature communications · 2016Article
- Reinforcement of the Brain's Rich-Club Architecture Following Early Neurodevelopmental Disruption Caused by Very Preterm Birth.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
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10 authors.
Funding
Abstract
backgroundThe hippocampus has been reported to be structurally and functionally altered as a sequel of very preterm birth (<33 weeks gestation), possibly due its vulnerability to hypoxic-ischemic damage in the neonatal period. We examined hippocampal volumes and subregional morphology in very preterm born individuals in mid- and late adolescence and their association with psychiatric outcome.
methodsStructural brain magnetic resonance images were acquired at two time points (baseline and follow-up) from 65 ex-preterm adolescents (mean age = 15.5 and 19.6 years) and 36 term-born controls (mean age=15.0 and 19.0 years). Hippocampal volumes and subregional morphometric differences were measured from manual tracings and with three-dimensional shape analysis. Psychiatric outcome was assessed with the Rutter Parents' Scale at baseline, the General Health Questionnaire at follow-up and the Peters Delusional Inventory at both time points.
resultsIn contrast to previous studies we did not find significant difference in the cross-sectional or longitudinal hippocampal volumes between individuals born preterm and controls, despite preterm individual having significantly smaller whole brain volumes. Shape analysis at baseline revealed subregional deformations in 28% of total bilateral hippocampal surface, reflecting atrophy, in ex-preterm individuals compared to controls, and in 22% at follow-up. In ex-preterm individuals, longitudinal changes in hippocampal shape accounted for 11% of the total surface, while in controls they reached 20%. In the whole sample (both groups) larger right hippocampal volume and bilateral anterior surface deformations at baseline were associated with delusional ideation scores at follow-up.
conclusionsThis study suggests a dynamic association between cross-sectional hippocampal volumes, longitudinal changes and surface deformations and psychosis proneness.
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