Evidence map›Paper›PMID 26090820›Full record

ArticlePloS one2015

Symptoms of Obstructive Sleep Apnea, Gastroesophageal Reflux and the Risk of Barrett's Esophagus in a Population-Based Case-Control Study.

Anna Lindam, Bradley J Kendall, Aaron P Thrift, Graeme A Macdonald, Suzanne O'Brien, Jesper Lagergren, David C Whiteman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Anna LindamUpper GI Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Cancer Control Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Bradley J KendallCancer Control Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Department of Medicine, School of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Aaron P ThriftCancer Control Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Graeme A MacdonaldDepartment of Medicine, School of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Suzanne O'BrienCancer Control Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Jesper LagergrenUpper GI Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Division of Cancer Studies, King's College London, London, United Kingdom.
David C WhitemanCancer Control Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
QIMR Berghofer Medical Research Institute · AUKing's College London · GBUniversity of Queensland · AU

Funding

Molecular epidemiology of Barretts esophagus and cancerR01CA001833 · NCI · QUEENSLAND INSTITUTE OF MEDICAL RESEARCH · PI WHITEMAN, DAVID C · 2002 to 2006
$1.3M
NCI NIH HHS R01 CA001833
6 · The paper itself

Abstract

backgroundGastroesophageal reflux is overrepresented in people with obstructive sleep apnea (OSA) and it has been suggested that OSA worsens gastroesophageal reflux symptoms. Aggravated reflux might lead to an increased risk of Barrett's esophagus.

aimTo assess the association between sleep apnea symptoms and Barrett's esophagus.

methodsIncluded in a case-control study in Brisbane, Australia were 237 patients with histologically confirmed Barrett's esophagus and 247 population controls. The controls were randomly selected from the electoral roll and frequency-matched to the cases by age and sex. Information on OSA symptoms (excessive daytime sleepiness and sleep related apnea symptoms), gastroesophageal reflux symptoms and anthropometric measures were collected through interviews and written questionnaires. Multivariable logistic regression provided odds ratios (OR) and 95% confidence intervals (CI), adjusted for potential confounding by BMI and gastroesophageal reflux.

resultsThe prevalence of Barrett's esophagus was higher among people with excessive daytime sleepiness than those without (24% vs. 18%; p-value 0.1142) and in participants with sleep-related apnea symptoms (20% vs. 13%; p-value 0.1730). However, there were non-significantly increased ORs of Barrett's esophagus among people with excessive daytime sleepiness (OR 1.42, 95% CI 0.90-2.34) and sleep related apnea symptoms (OR 1.32, 95% CI 0.74-2.36) when adjusting for age, sex and BMI. After further adjustment for gastroesophageal reflux symptoms, the point ORs were no longer increased (OR 1.02, 95% CI 0.61-1.70 for daytime sleepiness and OR 0.72, 95% CI 0.38-1.38 for sleep related apnea symptoms).

conclusionsSymptoms of OSA are possibly associated with an increased risk of Barrett's esophagus, an association that appears to be mediated entirely by gastroesophageal reflux.

Indexed as

Population SurveillanceAdultAgedAged, 80 and overAustraliaBarrett EsophagusCase-Control StudiesFemaleGastroesophageal RefluxHumansMaleMiddle AgedOdds RatioRiskSleep Apnea, ObstructiveYoung Adult

Identifiers

PMID26090820
PMCPMC4474428
OpenAlexW623216429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.