ArticleEnvironmental health perspectives2016
Use of the Adaptive LASSO Method to Identify PM2.5 Components Associated with Blood Pressure in Elderly Men: The Veterans Affairs Normative Aging Study.
Article in Environmental health perspectives, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 69 citations in OpenAlex.
- Prediction of positive pulmonary nodules based on machine learning algorithm combined with central carbon metabolism data.Journal of cancer research and clinical oncology · 2024Article
- A review of common statistical methods for dealing with multiple pollutant mixtures and multiple exposures.Frontiers in public health · 2024Review
- Long-term exposure to ambient PM2.5 and its constituents is associated with MAFLD.JHEP reports : innovation in hepatology · 2023Article
- Long-term exposure to ambient fine particulate components and leukocyte epigenome-wide DNA Methylation in older men: the Normative Aging Study.Environmental health : a global access science source · 2023Article
- Targeted metabolomics reveals the association between central carbon metabolism and pulmonary nodules.PloS one · 2023Article
- Factors Influencing Classroom Exposures to Fine Particles, Black Carbon, and Nitrogen Dioxide in Inner-City Schools and Their Implications for Indoor Air Quality.Environmental health perspectives · 2022Article
- Exposure to Metal Mixtures in Association with Cardiovascular Risk Factors and Outcomes: A Scoping Review.Toxics · 2022Article
- Residential greenness attenuated association of long-term air pollution exposure with elevated blood pressure: Findings from polluted areas in Northern China.Frontiers in public health · 2022Article
- Short- and intermediate-term exposure to ambient fine particulate elements and leukocyte epigenome-wide DNA methylation in older men: the Normative Aging Study.Environment international · 2022Article
- Long-Term Exposures to Air Pollution and the Risk of Atrial Fibrillation in the Women's Health Initiative Cohort.Environmental health perspectives · 2021Article
- Associations Between Serum Multiple Metals Exposures and Metabolic Syndrome: a Longitudinal Cohort Study.Biological trace element research · 2021Article
- Associations between PMEnvironmental research · 2021Article
- Ambient Particle Components and Newborn Blood Pressure in Project Viva.Journal of the American Heart Association · 2021Article
- The Association Between Long-Term Exposure to Particulate Matter and Incidence of Hypertension Among Chinese Elderly: A Retrospective Cohort Study.Frontiers in cardiovascular medicine · 2021Article
- [Combined effects of different environmental factors on health: air pollution, temperature, green spaces, pollen, and noise].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2020Review
- The Gender-Based Differences in Vulnerability to Ambient Air Pollution and Cerebrovascular Disease Mortality: Evidences Based on 26781 Deaths.Global heart · 2020Article
- Association between ambient fine particulate matter with blood pressure levels among Iranian individuals admitted for cardiac and respiratory diseases: Data from CAPACITY study.ARYA atherosclerosis · 2020Article
- Evaluating associations between early pregnancy trace elements mixture and 2nd trimester gestational glucose levels: A comparison of three statistical approaches.International journal of hygiene and environmental health · 2020Article
- Source-Apportioned PM2.5 and Cardiorespiratory Emergency Department Visits: Accounting for Source Contribution Uncertainty.Epidemiology (Cambridge, Mass.) · 2019Article
- Refining the World Health Organization Definition: Predicting Autopsy-Defined Sudden Arrhythmic Deaths Among Presumed Sudden Cardiac Deaths in the POST SCD Study.Circulation. Arrhythmia and electrophysiology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPM2.5 (particulate matter ≤ 2.5 μm) has been associated with adverse cardiovascular outcomes, but it is unclear whether specific PM2.5 components, particularly metals, may be responsible for cardiovascular effects.
objectivesWe aimed to determine which PM2.5 components are associated with blood pressure in a longitudinal cohort.
methodsWe fit linear mixed-effects models with the adaptive LASSO penalty to longitudinal data from 718 elderly men in the Veterans Affairs Normative Aging Study, 1999-2010. We controlled for PM2.5 mass, age, body mass index, use of antihypertensive medication (ACE inhibitors, non-ophthalmic beta blockers, calcium channel blockers, diuretics, and angiotensin receptor antagonists), smoking status, alcohol intake, years of education, temperature, and season as fixed effects in the models, and additionally applied the adaptive LASSO method to select PM2.5 components associated with blood pressure. Final models were identified by the Bayesian Information Criterion (BIC).
resultsFor systolic blood pressure (SBP), nickel (Ni) and sodium (Na) were selected by the adaptive LASSO, whereas only Ni was selected for diastolic blood pressure (DBP). An interquartile range increase (2.5 ng/m3) in 7-day moving-average Ni was associated with 2.48-mmHg (95% CI: 1.45, 3.50 mmHg) increase in SBP and 2.22-mmHg (95% CI: 1.69, 2.75 mmHg) increase in DBP, respectively. Associations were comparable when the analysis was restricted to study visits with PM2.5 below the 75th percentile of the distribution (12 μg/m3).
conclusionsOur study suggested that exposure to ambient Ni was associated with increased blood pressure independent of PM2.5 mass in our study population of elderly men. Further research is needed to confirm our findings, assess generalizability to other populations, and identify potential mechanisms for Ni effects. CITATION: Dai L, Koutrakis P, Coull BA, Sparrow D, Vokonas PS, Schwartz JD. 2016. Use of the adaptive LASSO method to identify PM2.5 components associated with blood pressure in elderly men: the Veterans Affairs Normative Aging Study. Environ Health Perspect 124:120-125; http://dx.doi.org/10.1289/ehp.1409021.
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