ArticlePLoS genetics2015
Transfer RNAs Mediate the Rapid Adaptation of Escherichia coli to Oxidative Stress.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 101 citations in OpenAlex.
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- Investigation of the global translational response to oxidative stress in the model archaeonmSphere · 2025Article
- RecA Inhibitor Mitigates Bacterial Antibiotic Resistance.Microorganisms · 2025Article
- Unveiling the regulatory role of GRP7 in ABA signal-mediated mRNA translation efficiency regulation.Nature communications · 2025Article
- Multi-kingdom microbial assemblage modulates its metabolism under contrasted cloud conditions.ISME communications · 2025Article
- Selective 8-oxo-rG stalling occurs in the catalytic core of polynucleotide phosphorylase (PNPase) during degradation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Dynamics of diversified A-to-I editing in Streptococcus pyogenes is governed by changes in mRNA stability.Nucleic acids research · 2024Article
- Epigenetic modifications of DNA and RNA in Alzheimer's disease.Frontiers in molecular neuroscience · 2024Review
- TudS desulfidases recycle 4-thiouridine-5'-monophosphate at a catalytic [4Fe-4S] cluster.Communications biology · 2023Article
- Profiling of the Helicobacter pylori redox switch HP1021 regulon using a multi-omics approach.Nature communications · 2023Article
- The Arsenal ofAntioxidants (Basel, Switzerland) · 2023Review
- Article
- Adaptation delay causes a burst of mutations in bacteria responding to oxidative stress.EMBO reports · 2023Article
- Global and gene-specific translational regulation in Escherichia coli across different conditions.PLoS computational biology · 2022Article
- The oxidative stress and metabolic response of Acinetobacter baumannii for aPDT multiple photosensitization.Scientific reports · 2022Article
- Weight Change Alters the Small RNA Profile of Urinary Extracellular Vesicles in Obesity.Obesity facts · 2022Article
- Biological effects of Thymol loaded chitosan nanoparticles (TCNPs) on bacterial plant pathogenFrontiers in microbiology · 2022Article
- Oxidative stress strongly restricts the effect of codon choice on the efficiency of protein synthesis inFrontiers in microbiology · 2022Article
- Sigma factor RpoS positively affects the spoilage activity ofFrontiers in microbiology · 2022Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Translational systems can respond promptly to sudden environmental changes to provide rapid adaptations to environmental stress. Unlike the well-studied translational responses to oxidative stress in eukaryotic systems, little is known regarding how prokaryotes respond rapidly to oxidative stress in terms of translation. In this study, we measured protein synthesis from the entire Escherichia coli proteome and found that protein synthesis was severely slowed down under oxidative stress. With unchanged translation initiation, this slowdown was caused by decreased translation elongation speed. We further confirmed by tRNA sequencing and qRT-PCR that this deceleration was caused by a global, enzymatic downregulation of almost all tRNA species shortly after exposure to oxidative agents. Elevation in tRNA levels accelerated translation and protected E. coli against oxidative stress caused by hydrogen peroxide and the antibiotic ciprofloxacin. Our results showed that the global regulation of tRNAs mediates the rapid adjustment of the E. coli translation system for prompt adaptation to oxidative stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.