ArticleThe Pediatric infectious disease journal2015
Brain Imaging and Neurodevelopment in HIV-uninfected Thai Children Born to HIV-infected Mothers.
Article in The Pediatric infectious disease journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- In utero exposure to HIV and/or antiretroviral therapy: a systematic review of preclinical and clinical evidence of cognitive outcomes.Journal of the International AIDS Society · 2019Pooled it
- Head circumferences of children born to HIV-infected and HIV-uninfected mothers in Zimbabwe during the preantiretroviral therapy era.AIDS (London, England) · 2016Trial
- Lower working memory and processing speed among children and youth exposed to HIV.AIDS (London, England) · 2026Article
- Feasibility of Brain Ultrasound Performed by Nurses in the Evaluation of Newborns Who Are HIV Exposed in Utero and Uninfected: A Pilot Study in Botswana.Children (Basel, Switzerland) · 2024Article
- Understanding the impact of congenital infections and perinatal viral exposures on the developing brain using white matter magnetic resonance imaging: a scoping review.BMC medical imaging · 2024Article
- Distinct alterations in white matter properties and organization related to maternal treatment initiation in neonates exposed to HIV but uninfected.Scientific reports · 2024Article
- Association of in utero HIV exposure with child brain structure and language development: a South African birth cohort study.BMC medicine · 2024Article
- Distinct alterations in white matter properties and organization related to maternal treatment initiation in neonates exposed to HIV but uninfected.bioRxiv : the preprint server for biology · 2024Article
- Maternal ART throughout gestation prevents caudate volume reductions in neonates who are HIV exposed but uninfected.Frontiers in neuroscience · 2023Article
- Altered White Matter Tracts in the Somatosensory, Salience, Motor, and Default Mode Networks in 7-Year-Old Children Living with Human Immunodeficiency Virus: A Tractographic Analysis.Brain connectivity · 2022Article
- Evaluating Neurodevelopmental Consequences of Perinatal Exposure to Antiretroviral Drugs: Current Challenges and New Approaches.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021Review
- State of the Mind: Growing up with HIV.Paediatric drugs · 2020Review
- Neuroimaging young children and associations with neurocognitive development in a South African birth cohort study.NeuroImage · 2020Article
- Cognitive and Language Development at Age 4-6 Years in Children HIV-Exposed But Uninfected Compared to Those HIV-Unexposed and to Children Living With HIV.New directions for child and adolescent development · 2020Article
- Brain microstructural changes support cognitive deficits in HIV uninfected children born to HIV infected mothers.Brain, behavior, & immunity - health · 2020Article
- White matter microstructure among perinatally HIV-infected youth: a diffusion tensor imaging study.Journal of neurovirology · 2019Article
- Structural Neuroimaging and Neuropsychologic Signatures in Children With Vertically Acquired HIV.The Pediatric infectious disease journal · 2018Article
- Structural Covariance of Gray Matter Volume in HIV Vertically Infected Adolescents.Scientific reports · 2018Article
- Perinatal HIV Infection or Exposure Is Associated With LowFrontiers in human neuroscience · 2018Article
- ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide.NeuroImage · 2017Review
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17 authors.
Funding
Abstract
backgroundPerinatal use of combination antiretroviral therapy dramatically reduces vertical (mother-to-child) transmission of HIV but has led to a growing population of children with perinatal HIV-exposure but uninfected (HEU). HIV can cause neurological injury among children born with infection, but the neuroanatomical and developmental effects in HEU children are poorly understood.
methodsWe used structural magnetic resonance imaging with diffusion tensor imaging to compare brain anatomy between 30 HEU and 33 age-matched HIV-unexposed and uninfected (HUU) children from Thailand. Maps of brain volume and microstructural anatomy were compared across groups; associations were tested between neuroimaging measures and concurrent neuropsychological test performance.
resultsMean (standard deviation) age of children was 10.3 (2.8) years, and 58% were male. All were enrolled in school and lived with family members. Intelligence quotient (IQ) did not differ between groups. Caretaker education levels did not differ, but income was higher for HUU (P < 0.001). We did not detect group differences in brain volume or diffusion tensor imaging metrics, after controlling for sociodemographic factors. The mean (95% confidence interval) fractional anisotropy in the corpus callosum was 0.375 (0.368-0.381) in HEU compared with 0.370 (0.364-0.375) in HUU. Higher fractional anisotropy and lower mean diffusivity were each associated with higher IQ scores in analyses with both groups combined.
conclusionsNo differences in neuroanatomical or brain integrity measures were detectable in HEU children compared with age-matched and sex-matched controls (HUU children). Expected associations between brain integrity measures and IQ scores were identified suggesting sufficient power to detect subtle associations that were present.
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