ArticleJournal of toxicology and environmental health. Part A2015
Effects of Maternal Exposure to Cadmium Oxide Nanoparticles During Pregnancy on Maternal and Offspring Kidney Injury Markers Using a Murine Model.
Article in Journal of toxicology and environmental health. Part A, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cadmium Associated Preeclampsia: A Systematic Literature Review of Pregnancy and Birth Outcomes.Biological trace element research · 2025Pooled it
- Evaluating NIR-II-Emissive Graphene Quantum Dot Biodistribution, Toxicity, and Clearance forACS applied nano materials · 2026Article
- The effects of developmental cadmium exposure on health and disease.Disease models & mechanisms · 2025Review
- Melatonin may protect the gastrointestinal system from cadmium chloride toxicity during pregnancy.Toxicology research · 2025Article
- Article
- Roles of airway and intestinal epithelia in responding to pathogens and maintaining tissue homeostasis.Frontiers in cellular and infection microbiology · 2024Review
- A Review of in vivo Toxicity of Quantum Dots in Animal Models.International journal of nanomedicine · 2023Review
- Cadmium Sulfide Quantum Dots Adversely Affect Gametogenesis inNanomaterials (Basel, Switzerland) · 2022Article
- Developmental toxicity of cadmium in infants and children: a review.Environmental analysis, health and toxicology · 2021Article
- Adverse Impact of Environmental Chemicals on Developmental Origins of Kidney Disease and Hypertension.Frontiers in endocrinology · 2021Review
- Prenatal Exposure to Gutkha, a Globally Relevant Smokeless Tobacco Product, Induces Hepatic Changes in Adult Mice.International journal of environmental research and public health · 2020Article
- Effect of Gestational Age on Maternofetal Vascular Function Following Single Maternal Engineered Nanoparticle Exposure.Cardiovascular toxicology · 2019Article
- Biological monitoring of workers exposed to engineered nanomaterials.Toxicology letters · 2018Review
- Engineered nanomaterial applications in perinatal therapeutics.Pharmacological research · 2018Review
- Maternal engineered nanomaterial inhalation during gestation alters the fetal transcriptome.Particle and fibre toxicology · 2018Article
- Nanoparticles and female reproductive system: how do nanoparticles affect oogenesis and embryonic development.Oncotarget · 2017Review
- Cadmium Handling, Toxicity and Molecular Targets Involved during Pregnancy: Lessons from Experimental Models.International journal of molecular sciences · 2017Review
- Inhaled Cadmium Oxide Nanoparticles: Their in Vivo Fate and Effect on Target Organs.International journal of molecular sciences · 2016Article
- Impacts of prenatal nanomaterial exposure on male adult Sprague-Dawley rat behavior and cognition.Journal of toxicology and environmental health. Part A · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Nanoparticles (NP) are pervasive in many areas of modern life, with little known about their potential toxicities. One commercially important NP is cadmium oxide (CdO), which is used to synthesize other Cd-containing NP, such as quantum dots. Cadmium (Cd) is a well-known nephrotoxicant, but the nephrotoxic potential of CdO NP remains unknown, particularly when exposure occurs during pregnancy. Therefore, pregnant CD-1 mice were used to examine the effects of inhaled CdO NP (230 μg CdO NP/m(3)) on maternal and neonatal renal function by examining urinary creatinine and urinary biomarkers of kidney injury, including kidney injury molecule-1 (Kim-1) and neutrophil gelatinase-associated lipocalin (NGAL). Inhalation of CdO NP by dams produced a fivefold increase in urinary Kim-1 with no marked effect on urinary creatinine levels. Kim-1 mRNA expression peaked by gestational day (GD) 10.5, and NGAL expression increased from GD 10.5 to 17.5. In addition, histological analyses revealed proximal tubular pathology at GD 10.5. Neonatal Kim-1 mRNA expression rose between postnatal days (PND) 7 and 14, with mammary glands/milk being the apparent source of Cd for offspring. These studies demonstrate that, similar to what is seen with other Cd forms, Cd associated with inhaled CdO NP results in renal injury to both directly exposed dam and offspring. As commercial uses for nanotechnology continue to expand throughout the world, risks for unintentional exposure in the workplace increase. Given the large number of women in the industrial workforce, care needs to be taken to protect these already vulnerable populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.