Evidence map›Paper›PMID 26090492›Full record

ReviewJournal of immunology research2015

Interactions between Innate Immunity, Microbiota, and Probiotics.

GianMarco Giorgetti, Giovanni Brandimarte, Federica Fabiocchi, Salvatore Ricci, Paolo Flamini, Giancarlo Sandri, Maria Cristina Trotta, Walter Elisei, Antonio Penna, Piera Giuseppina Lecca and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of immunology research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 98 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Immunostimulatory effects ofInfection and immunity · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Can Postbiotics Represent a New Strategy for NEC?Advances in experimental medicine and biology · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Microbiota Composition in Diverticular Disease: Implications for Therapy.International journal of molecular sciences · 2022
    Review
  13. Nutrients · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Frontiers in microbiology · 2022
    Article
  18. Frontiers in microbiology · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

GianMarco GiorgettiDigestive Endoscopy & Nutrition Unit, "S. Eugenio" Hospital, Piazzale dell'Umanesimo 10, 00144 Rome, Italy.
Giovanni BrandimarteDivision of Internal Medicine and Gastroenterology, "Cristo Re" Hospital, Via delle Calasanziane 25, 00167 Rome, Italy.
Federica FabiocchiClinical Nutrition Unit, "S. Eugenio" Hospital, Piazzale dell'Umanesimo 10, 00144 Rome, Italy.
Salvatore RicciClinical Nutrition Unit, "Umberto I" Hospital, Viale del Policliniuco 185, 00186 Rome, Italy.
Paolo FlaminiClinical Nutrition Unit, "Umberto I" Hospital, Viale del Policliniuco 185, 00186 Rome, Italy.
Giancarlo SandriClinical Nutrition Unit, "S. Eugenio" Hospital, Piazzale dell'Umanesimo 10, 00144 Rome, Italy.
Maria Cristina TrottaDivision of Internal Medicine, "S. Eugenio" Hospital, Piazzale dell'Umanesimo 10, 00144 Rome, Italy.
Walter EliseiDivision of Gastroenterology, ASL Roma H, Via Borgo Garibaldi 12, Albano Laziale, 00041 Rome, Italy.
Antonio PennaDivision of Gastroenterology, "S. Paolo" Hospital, Contrada Capo Scardicchio 82, 00123 Bari, Italy.
Piera Giuseppina LeccaDivision of Internal Medicine and Gastroenterology, "Cristo Re" Hospital, Via delle Calasanziane 25, 00167 Rome, Italy.
Marcello PicchioDivision of General Surgery, "P. Colombo" Hospital, ASL Roma H, Via Orti Ginnetti 7, Velletri, 00049 Rome, Italy.
Antonio TursiGastroenterology Service, ASL BAT, Via Torino 49, 76123 Andria, Italy.ORCID 0000-0001-5767-5541
St. Eugenio Hospital · ITASL Roma · ITOspedale Cristo Re · ITPoliclinico Umberto I · ITOspedale L. Bonomo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The term "microbiota" means genetic inheritance associated with microbiota, which is about 100 times larger than the guest. The tolerance of the resident bacterial flora is an important key element of immune cell function. A key role in the interaction between the host and the microbiota is played by Paneth cell, which is able to synthesize and secrete proteins and antimicrobial peptides, such as α/β defensins, cathelicidin, 14 β-glycosidases, C-type lectins, and ribonuclease, in response to various stimuli. Recent studies found probiotics able to preserve intestinal homeostasis by downmodulating the immune response and inducing the development of T regulatory cells. Specific probiotic strain, as well as probiotic-driven metabolic products called "postbiotics," has been recently recognized and it is able to influence innate immunity. New therapeutic approaches based on probiotics are now available, and further treatments based on postbiotics will come in the future.

Indexed as

AnimalsHumansImmunity, InnateMicrobiotaPaneth CellsProbiotics

Identifiers

PMID26090492
PMCPMC4451779
OpenAlexW1513197571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.