Evidence map›Paper›PMID 26090488›Full record

SynthesisJournal of immunology research2015

Interleukin-23R rs7517847 T/G Polymorphism Contributes to the Risk of Crohn's Disease in Caucasians: A Meta-Analysis.

Li Zhang, Yunjie Lu, Yuzheng Ge, Yun Shi, Xing Wu, Qinghua Xu, Xiaoping Li, Ling Lu, Feng Zhang, Guozhong Yao

Open access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of immunology research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Multi-omics in Crohn's disease: New insights from inside.Computational and structural biotechnology journal · 2023
    Review
  2. Relationship between theInternational journal of environmental research and public health · 2019
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Li ZhangLiyang People's Hospital, Liyang 213300, China.ORCID 0000-0003-3757-6065
Yunjie LuTranslational Medicine Research Center of Jiangning Hospital and Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Yuzheng GeDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China.
Yun ShiLiyang People's Hospital, Liyang 213300, China.
Xing WuLiyang People's Hospital, Liyang 213300, China.
Qinghua XuLiyang People's Hospital, Liyang 213300, China.
Xiaoping LiLiyang People's Hospital, Liyang 213300, China.
Ling LuTranslational Medicine Research Center of Jiangning Hospital and Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Feng ZhangTranslational Medicine Research Center of Jiangning Hospital and Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Guozhong YaoLiyang People's Hospital, Liyang 213300, China.
Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The association between Interleukin-23R gene polymorphism and Crohn's disease (CD) in Caucasians is still controversial. Thus, a meta-analysis was performed to evaluate the correlation between this gene variant and CD risk. We retrieved the available data from EMBASE and PUBMED until May 1, 2014, and evaluated the effect of rs7517847 in Caucasians. The significant associations were confirmed between rs7517847 and CD risk in dominant models (TT/TG versus GG: OR = 1.652, 95% CI 1.277, 2.137), allelic model (T allele versus G allele: OR = 1.327, 95% CI 1.198, 1.469), homozygote comparison (TT versus GG: OR = 1.890, 95% CI 1.465, 2.437), heterozygote comparison (TG versus GG: OR = 1.509, 95% CI 1.161, 1.960), and recessive model (TT versus TG/GG: OR = 1.409, 95% CI 1.279, 1.552). In conclusion, this meta-analysis demonstrates that rs7517847 is associated with the risk of CD in Caucasians. These findings show that IL-23R genes confer susceptibility to CD in the Caucasians.

Indexed as

AllelesCrohn DiseaseGenetic Predisposition to DiseaseGenotypeHeterozygoteHumansPolymorphism, Single NucleotideReceptors, InterleukinRisk FactorsWhite PeopleIL23R protein, humanReceptors, Interleukin

Identifiers

PMID26090488
PMCPMC4451526
OpenAlexW1534317053

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.