High Intensity Interval Training Favourably Affects Angiotensinogen mRNA Expression and Markers of Cardiorenal Health in a Rat Model of Early-Stage Chronic Kidney Disease.

Patrick S Tucker, Aaron T Scanlan, Vincent J Dalbo

Abstract read

In one paragraph

Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it

0cells of the map it votes in

8citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

Associations of accelerometer-derived physical activity with chronic kidney disease risk in a population with hypertension: a prospective cohort study.BMC nephrology · 2026
Article
Moderate intensity continuous training mitigates hypertension-induced renal fibrosis by inhibiting HIF-1α-mediated autophagy.Frontiers in physiology · 2025
Article
High-Intensity Interval Training Improves Glycemic Control, Cellular Apoptosis, and Oxidative Stress of Type 2 Diabetic Patients.Medicina (Kaunas, Lithuania) · 2023
Article
Identification of exercise-regulated genes in mice exposed to cigarette smoke.Physiological reports · 2022
Article
The effects of exercise on kidney injury: the role of SIRT1.Molecular biology reports · 2022
Review
Effect of different intensities of physical activity on cardiometabolic markers and vascular and cardiac function in adult rats fed with a high-fat high-carbohydrate diet.Journal of sport and health science · 2018
Article
Beneficial Effect of Moderate Exercise in Kidney of Rat after Chronic Consumption of Cola Drinks.PloS one · 2016
Article
Genomic Integrity Is Favourably Affected by High-Intensity Interval Training in an Animal Model of Early-Stage Chronic Kidney Disease.Sports medicine - open · 2015
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Patrick S TuckerClinical Biochemistry Laboratory, Central Queensland University, Building 81, Bruce Highway, Rockhampton, QLD 4702, Australia ; Human Exercise and Training Laboratory, Central Queensland University, Building 81, Bruce Highway, Rockhampton, QLD 4702, Australia.

Aaron T ScanlanClinical Biochemistry Laboratory, Central Queensland University, Building 81, Bruce Highway, Rockhampton, QLD 4702, Australia ; Human Exercise and Training Laboratory, Central Queensland University, Building 81, Bruce Highway, Rockhampton, QLD 4702, Australia.

Vincent J DalboClinical Biochemistry Laboratory, Central Queensland University, Building 81, Bruce Highway, Rockhampton, QLD 4702, Australia ; Human Exercise and Training Laboratory, Central Queensland University, Building 81, Bruce Highway, Rockhampton, QLD 4702, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The majority of CKD-related complications stem from cardiovascular pathologies such as hypertension. To help reduce cardiovascular complications, aerobic exercise is often prescribed. Emerging evidence suggests high intensity interval training (HIIT) may be more beneficial than traditional aerobic exercise. However, appraisals of varying forms of aerobic exercise, along with descriptions of mechanisms responsible for health-related improvements, are lacking. This study examined the effects of 8 weeks of HIIT (85% VO2max), versus low intensity aerobic exercise (LIT; 45-50% VO2max) and sedentary behaviour (SED), in an animal model of early-stage CKD. Tissue-specific mRNA expression of RAAS-related genes and CKD-related clinical markers were examined. Compared to SED, HIIT resulted in increased plasma albumin (p = 0.001), reduced remnant kidney weight (p = 0.028), and reduced kidney weight-body weight ratios (p = 0.045). Compared to LIT, HIIT resulted in reduced Agt mRNA expression (p = 0.035), reduced plasma LDL (p = 0.001), triglycerides (p = 0.029), and total cholesterol (p = 0.002), increased plasma albumin (p = 0.047), reduced remnant kidney weight (p = 0.005), and reduced kidney weight-body weight ratios (p = 0.048). These results suggest HIIT is a more potent regulator of several markers that describe and influence health in CKD.

Indexed as

Exercise TherapyAngiotensinogenAnimalsDisease Models, AnimalHumansHypertensionMaleRatsRenal Insufficiency, ChronicRNA, MessengerSerum AlbuminTriglyceridesAngiotensinogenRNA, MessengerSerum AlbuminTriglycerides

Identifiers

PMID26090382

DOI10.1155/2015/156584

PMCPMC4458272

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.