Evidence map›Paper›PMID 26090275›Full record

ArticlePlastic and reconstructive surgery. Global open2015

Craniofacial Measurements of Donors and Recipients Correlate with Aesthetic Outcome in Virtual Face Transplantation.

Joseph S Wallins, Akash A Chandawarkar, Allison Dobry, J Rodrigo Diaz-Siso, Ericka M Bueno, Edward J Caterson, Camille Jania, Nathanael D Hevelone, Stuart R Lipsitz, Srinivasan Mukundan and 1 more

Abstract read
PubMed Full text at PMC Publisher
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Article in Plastic and reconstructive surgery. Global open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joseph S WallinsDivision of Plastic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.; Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, Mass.; and Division of Neuroradiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Akash A ChandawarkarDivision of Plastic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.; Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, Mass.; and Division of Neuroradiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Allison DobryDivision of Plastic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.; Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, Mass.; and Division of Neuroradiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
J Rodrigo Diaz-SisoDivision of Plastic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.; Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, Mass.; and Division of Neuroradiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Ericka M BuenoDivision of Plastic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.; Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, Mass.; and Division of Neuroradiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Edward J CatersonDivision of Plastic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.; Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, Mass.; and Division of Neuroradiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Camille JaniaDivision of Plastic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.; Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, Mass.; and Division of Neuroradiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Nathanael D HeveloneDivision of Plastic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.; Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, Mass.; and Division of Neuroradiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Stuart R LipsitzDivision of Plastic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.; Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, Mass.; and Division of Neuroradiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Srinivasan MukundanDivision of Plastic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.; Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, Mass.; and Division of Neuroradiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Bohdan PomahacDivision of Plastic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.; Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, Mass.; and Division of Neuroradiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFace transplantation is an increasingly feasible option for patients with severe disfigurement. Donors and recipients are currently matched based on immune compatibility, skin characteristics, age, and gender. Aesthetic outcomes of the match are not always optimal and not possible to study in actual cases due to ethical and logistical challenges. We have used a reproducible and inexpensive three-dimensional virtual face transplantation (VFT) model to study this issue.

methodsSixty-one VFTs were performed using reconstructed high-resolution computed tomography angiographs of male and female subjects aged 20-69 years. Twenty independent reviewers evaluated the level of disfigurement of the posttransplant models. Absolute differences in 9 soft-tissue measurements and 16 bony cephalometric measurements from each of the VFT donor and recipient pretransplant model pairs were correlated to the reviewers' evaluation of disfigurement after VFT through a multivariate logistic regression model.

resultsFive soft-tissue measurements and 3 bony measurements were predictive of the rating of disfigurement after VFT (odds ratio; 95% confidence interval): trichion-to-nasion facial height (1.106; 1.066-1.148), endocanthal width (1.096; 1.051-1.142), exocanthal width (1.067; 1.036-1.099), mouth/chelion width (1.064; 1.019-1.110), subnasale-to-menton facial height (1.029; 1.003-1.056), inner orbit width (1.039; 1.009-1.069), palatal plane/occlusal plane angle (1.148; 1.047-1.258), and sella-nasion/mandibular plane angle (1.079; 1.013-1.150).

conclusionsThis study provides early evidence for the importance of soft-tissue and bony measurements in planning of facial transplantation. With future improvements to immunosuppressive regimens and increased donor availability, these measurements may be used as an additional criterion to optimize posttransplant outcomes.

Identifiers

PMID26090275
PMCPMC4457248

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