ArticleGenetics research international2015
Genome-Wide Gene Expression in relation to Age in Large Laboratory Cohorts of Drosophila melanogaster.
Article in Genetics research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Characterization of transcriptomics during aging and genes required for lifespan in Drosophila intestine.Scientific reports · 2025Article
- Dynamic changes in gene expression through aging in Drosophila melanogaster heads.G3 (Bethesda, Md.) · 2025Article
- Dynamic Changes in Gene Expression Through Aging inbioRxiv : the preprint server for biology · 2024Article
- Review
- The genomic basis of copper tolerance in Drosophila is shaped by a complex interplay of regulatory and environmental factors.BMC biology · 2022Article
- Article
- Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation inMolecular biology of the cell · 2021Article
- The Y chromosome may contribute to sex-specific ageing in Drosophila.Nature ecology & evolution · 2020Article
- Transcriptome Analysis of Long-lived Drosophila melanogaster E(z) Mutants Sheds Light on the Molecular Mechanisms of Longevity.Scientific reports · 2019Article
- Aging in the Drosophila ovary: contrasting changes in the expression of the piRNA machinery and mitochondria but no global release of transposable elements.BMC genomics · 2019Article
- Ribosomal DNA harbors an evolutionarily conserved clock of biological aging.Genome research · 2019Article
- Article
- The Neuronal Overexpression ofFrontiers in genetics · 2019Article
- Gene expression hallmarks of cellular ageing.Biogerontology · 2018Review
- Analysis of natural female post-mating responses of Anopheles gambiae and Anopheles coluzzii unravels similarities and differences in their reproductive ecology.Scientific reports · 2018Article
- The interplay between immunity and aging inF1000Research · 2018Review
- Genetic analysis of variation in lifespan using a multiparental advanced intercross Drosophila mapping population.BMC genetics · 2016Article
- A dataset for assessing temporal changes in gene expression during the aging process of adult Drosophila melanogaster.Data in brief · 2016Article
- Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster.BMC genomics · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Aging is a complex process characterized by a steady decline in an organism's ability to perform life-sustaining tasks. In the present study, two cages of approximately 12,000 mated Drosophila melanogaster females were used as a source of RNA from individuals sampled frequently as a function of age. A linear model for microarray data method was used for the microarray analysis to adjust for the box effect; it identified 1,581 candidate aging genes. Cluster analyses using a self-organizing map algorithm on the 1,581 significant genes identified gene expression patterns across different ages. Genes involved in immune system function and regulation, chorion assembly and function, and metabolism were all significantly differentially expressed as a function of age. The temporal pattern of data indicated that gene expression related to aging is affected relatively early in life span. In addition, the temporal variance in gene expression in immune function genes was compared to a random set of genes. There was an increase in the variance of gene expression within each cohort, which was not observed in the set of random genes. This observation is compatible with the hypothesis that D. melanogaster immune function genes lose control of gene expression as flies age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.