Evidence map›Paper›PMID 26090224›Full record

ReviewSchizophrenia research and treatment2015

Twenty Years of Schizophrenia Research in the Northern Finland Birth Cohort 1966: A Systematic Review.

Erika Jääskeläinen, Marianne Haapea, Nina Rautio, Pauliina Juola, Matti Penttilä, Tanja Nordström, Ina Rissanen, Anja Husa, Emmi Keskinen, Riikka Marttila and 6 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Schizophrenia research and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Erika JääskeläinenCenter for Life Course Epidemiology and Systems Medicine, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Department of Psychiatry, Center for Clinical Neurosciences, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland.
Marianne HaapeaMedical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Department of Psychiatry, Center for Clinical Neurosciences, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Department of Psychiatry, Oulu University Hospital, P.O. Box 26, 90029 Oulu, Finland.
Nina RautioCenter for Life Course Epidemiology and Systems Medicine, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Unit of Primary Health Care, Oulu University Hospital, P.O. Box 10, 90029 Oulu, Finland.
Pauliina JuolaMedical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Department of Psychiatry, Center for Clinical Neurosciences, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Department of Psychiatry, Oulu University Hospital, P.O. Box 26, 90029 Oulu, Finland.
Matti PenttiläMedical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Department of Psychiatry, Center for Clinical Neurosciences, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Department of Psychiatry, Oulu University Hospital, P.O. Box 26, 90029 Oulu, Finland.
Tanja NordströmCenter for Life Course Epidemiology and Systems Medicine, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, 90014 Oulu, Finland.
Ina RissanenCenter for Life Course Epidemiology and Systems Medicine, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Department of Psychiatry, Center for Clinical Neurosciences, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland.
Anja HusaMedical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Department of Psychiatry, Center for Clinical Neurosciences, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Department of Psychiatry, Oulu University Hospital, P.O. Box 26, 90029 Oulu, Finland.
Emmi KeskinenCenter for Life Course Epidemiology and Systems Medicine, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Department of Psychiatry, Center for Clinical Neurosciences, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland.
Riikka MarttilaCenter for Life Course Epidemiology and Systems Medicine, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Department of Psychiatry, Center for Clinical Neurosciences, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland.
Svetlana FilatovaCenter for Life Course Epidemiology and Systems Medicine, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Department of Psychiatry, Center for Clinical Neurosciences, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Department of Psychiatry, Oulu University Hospital, P.O. Box 26, 90029 Oulu, Finland.
Tiina-Mari PaasoCenter for Life Course Epidemiology and Systems Medicine, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, 90014 Oulu, Finland.
Jenni KoivukangasDepartment of Psychiatry, Center for Clinical Neurosciences, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Aurora Doctoral Programme, Thule Institute, University of Oulu, P.O. Box 7300, Oulu, Finland.
Kristiina MoilanenMedical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Department of Psychiatry, Center for Clinical Neurosciences, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Department of Psychiatry, Oulu University Hospital, P.O. Box 26, 90029 Oulu, Finland.
Matti IsohanniDepartment of Psychiatry, Center for Clinical Neurosciences, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Department of Psychiatry, Oulu University Hospital, P.O. Box 26, 90029 Oulu, Finland.
Jouko MiettunenCenter for Life Course Epidemiology and Systems Medicine, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Department of Psychiatry, Center for Clinical Neurosciences, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland ; Department of Psychiatry, Oulu University Hospital, P.O. Box 26, 90029 Oulu, Finland.ORCID 0000-0003-0575-2669
Oulu University Hospital · FIUniversity of Oulu · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Birth cohort designs are useful in studying adult disease trajectories and outcomes, such as schizophrenia. We review the schizophrenia research performed in the Northern Finland Birth Cohort 1966 (NFBC 1966), which includes 10,934 individuals living in Finland at 16 years of age who have been monitored since each mother's mid-pregnancy. By the age of 44, 150 (1.4%) had developed schizophrenia. There are 77 original papers on schizophrenia published from the NFBC 1966. The early studies have found various risk factors for schizophrenia, especially related to pregnancy and perinatal phase. Psychiatric and somatic outcomes were heterogeneous, but relatively poor. Mortality in schizophrenia is high, especially due to suicides. Several early predictors of outcomes have also been found. Individuals with schizophrenia have alterations in brain morphometry and neurocognition, and our latest studies have found that the use of high lifetime doses of antipsychotics associated with these changes. The schizophrenia research in the NFBC 1966 has been especially active for 20 years, the prospective study design and long follow-up enabling several clinically and epidemiologically important findings. When compared to other birth cohorts, the research in the NFBC 1966 has offered also unique findings on course and outcome of schizophrenia.

Identifiers

PMID26090224
PMCPMC4452001
OpenAlexW1587740123

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.