ArticleClinical research and trials
Effect of Maternal Cigarette Smoking on Newborn Iron Stores.
Article in Clinical research and trials. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Working group reports: evaluation of the evidence to support practice guidelines for nutritional care of preterm infants-the Pre-B Project.The American journal of clinical nutrition · 2016Pooled it
- Diet in Pregnancy: A Review of Current Challenges and Recommendations. A British Nutrition Foundation Briefing Paper.Nutrition bulletin · 2025Review
- Magnitude and determinants of anemia among patients at Garbo Primary Hospital, Somali Region of Ethiopia.Scientific reports · 2025Article
- Biospecimens in the HEALthy Brain and Child Development (HBCD) Study: Rationale and protocol.Developmental cognitive neuroscience · 2024Article
- Maternal levels of acute phase proteins in early pregnancy and risk of autism spectrum disorders in offspring.Translational psychiatry · 2022Article
- Cigarette Smoking during Pregnancy: Effects on Antioxidant Enzymes, Metallothionein and Trace Elements in Mother-Newborn Pairs.Biomolecules · 2020Article
- Active Tobacco Smoke Exposure in Utero and Concentrations of Hepcidin and Selected Iron Parameters in Newborns.International journal of environmental research and public health · 2019Article
- Passive smoking induces pediatric asthma by affecting the balance of Treg/Th17 cells.Pediatric research · 2019Article
- Predictors of anemia and iron status at birth in neonates born to women carrying multiple fetuses.Pediatric research · 2018Article
- Associations between Lifestyle Factors and Iron Overload in Korean Adults.Clinical nutrition research · 2016Article
- Hepcidin and Iron Metabolism in Pregnancy: Correlation with Smoking and Birth Weight and Length.Biological trace element research · 2016Observational
- Prenatal Alcohol Exposure Alters Fetal Iron Distribution and Elevates Hepatic Hepcidin in a Rat Model of Fetal Alcohol Spectrum Disorders.The Journal of nutrition · 2016Article
- Does Body Mass Index in Pregnant Women Affect Laboratory Parameters in the Newborn?AJP reports · 2016Article
- The role of iron in pulmonary pathology.Multidisciplinary respiratory medicine · 2015Article
- Smokeless Tobacco Exposure and Fetal Iron Status: An Analytical Study.Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineArticle
- Cigarette Smoke Particle-Induced Lung Injury and Iron Homeostasis.International journal of chronic obstructive pulmonary diseaseReview
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMaternal smoking has been known to have a negative impact on the well being of the developing fetus. Prenatal smoking has been associated with premature births, low birth weight and with certain birth defects. Small research studies have also found a negative correlation between maternal smoking and neonatal body iron.
objectivesTo study and compare the relationship between maternal and infants' body iron in smokers and non-smokers in a large matched-pair cohort.
methodsThis was a prospective cohort study involving 144 mothers - 72 smokers and 72 non-smokers and their respective infants. Samples were obtained from maternal and infants' cord blood at delivery for Serum transferrin receptor (sTfR) and ferritin levels. Serum TfR and ferritin were measured by RAMCO ELISA and RIA assays. Total Body Iron (TBI) was calculated using the sTfR/ferritin ratio in a previously described formula by Cook et al.
resultsWomen who smoked had lower sTfR, higher ferritin and higher body iron compared to nonsmoking women. In contrast to their respective mothers, we found a small, but statistically significant negative correlation between smoking and infants' total body iron. The number of packs per day smoked was also negatively correlated with infants' ferritin and total body iron. Lower birth weight was noted in babies of smokers compared to nonsmokers (mean /- SD =3270 +/-475 vs. 3393 g +/- 475 g, p=0.03).
conclusionWomen who smoked during pregnancy had higher iron stores but their newborn infants had lower iron stores than those of non-smoking mothers. The more packs per day (PPD) and more days smoked during pregnancy led to lower total body iron of the babies. There may be a negative dose-dependent response between fetal smoke exposure and infant iron stores.
Indexed as
Identifiers
26090215PMC4469279W1274647813What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.