ArticleFrontiers in genetics2015
PrOnto database : GO term functional dissimilarity inferred from biological data.
Article in Frontiers in genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- The role of 3'UTR-protein complexes in the regulation of protein multifunctionality and subcellular localization.Nucleic acids research · 2020Article
- Understanding protein multifunctionality: from short linear motifs to cellular functions.Cellular and molecular life sciences : CMLS · 2019Review
- MoonDB 2.0: an updated database of extreme multifunctional and moonlighting proteins.Nucleic acids research · 2019Article
- Multifunctional Proteins: Involvement in Human Diseases and Targets of Current Drugs.The protein journal · 2018Article
- Redefining protein moonlighting.Oncotarget · 2015Article
- Why study moonlighting proteins?Frontiers in genetics · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Moonlighting proteins are defined by their involvement in multiple, unrelated functions. The computational prediction of such proteins requires a formal method of assessing the similarity of cellular processes, for example, by identifying dissimilar Gene Ontology terms. While many measures of Gene Ontology term similarity exist, most depend on abstract mathematical analyses of the structure of the GO tree and do not necessarily represent the underlying biology. Here, we propose two metrics of GO term functional dissimilarity derived from biological information, one based on the protein annotations and the other on the interactions between proteins. They have been collected in the PrOnto database, a novel tool which can be of particular use for the identification of moonlighting proteins. The database can be queried via an web-based interface which is freely available at http://tagc.univ-mrs.fr/pronto.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.