ArticleFrontiers in plant science2015
Glucosinolate-derived isothiocyanates impact mitochondrial function in fungal cells and elicit an oxidative stress response necessary for growth recovery.
Article in Frontiers in plant science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 90 citations in OpenAlex.
- Shrimycocin-A, a next generation broad spectrum and systemic biofungicide from coconut shell agro waste for crop protection.Scientific reports · 2026Article
- Exploring the functional roles of secondary metabolites in Brassica defense networks.Journal of biosciences · 2026Review
- Glucosinolates in Human Health: Metabolic Pathways, Bioavailability, and Potential in Chronic Disease Prevention.Foods (Basel, Switzerland) · 2025Review
- Integrated Transcriptome and Metabolome Analysis Reveals the Resistance Mechanisms ofInternational journal of molecular sciences · 2025Article
- Proximity labelling suggests association of the nonhost receptor PSS1 protein with enzymes of multiple defense pathways in Arabidopsis.Frontiers in plant science · 2025Article
- Glucosinolates Mediated Regulation of Enzymatic Activity in Response to Oxidative Stress inPlants (Basel, Switzerland) · 2024Review
- Plant-Derived Antimicrobials and Their Crucial Role in Combating Antimicrobial Resistance.Antibiotics (Basel, Switzerland) · 2024Review
- Studying Salt-Induced Shifts in Gene Expression Patterns of Glucosinolate Transporters and Glucosinolate Accumulation in Two ContrastingMetabolites · 2024Article
- Plant defense compounds can enhance antagonistic effects againstFrontiers in plant science · 2024Article
- Spectral Reflectance Indexes Reveal Differences in the Physiological Status ofPlants (Basel, Switzerland) · 2023Article
- To Cut the Mustard: Antimicrobial Activity of Selenocyanates on the Plate and in the Gas Phase.Antibiotics (Basel, Switzerland) · 2023Article
- Glucosinolates, a natural chemical arsenal: More to tell than the myrosinase story.Frontiers in microbiology · 2023Review
- An Assessment of the In Vitro Models and Clinical Trials Related to the Antimicrobial Activities of Phytochemicals.Antibiotics (Basel, Switzerland) · 2022Review
- Antifungal Effect of Brassica Tissues on the Mycotoxigenic Cereal PathogenAntibiotics (Basel, Switzerland) · 2022Article
- Mitochondrial prohibitin complex regulates fungal virulence via ATG24-assisted mitophagy.Communications biology · 2022Article
- Seed Transmission of Pathogens: Non-Canonical Immune Response inPlants (Basel, Switzerland) · 2022Article
- Plant pathogenic bacterium can rapidly evolve tolerance to an antimicrobial plant allelochemical.Evolutionary applications · 2022Article
- Article
- Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives.Microorganisms · 2021Review
- Sclerotinia sclerotiorum Response to Long Exposure to Glucosinolate Hydrolysis Products by Transcriptomic Approach.Microbiology spectrum · 2021Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucosinolates are brassicaceous secondary metabolites that have long been considered as chemical shields against pathogen invasion. Isothiocyanates (ITCs), are glucosinolate-breakdown products that have negative effects on the growth of various fungal species. We explored the mechanism by which ITCs could cause fungal cell death using Alternaria brassicicola, a specialist Brassica pathogens, as model organism. Exposure of the fungus to ICTs led to a decreased oxygen consumption rate, intracellular accumulation of reactive oxygen species (ROS) and mitochondrial-membrane depolarization. We also found that two major regulators of the response to oxidative stress, i.e., the MAP kinase AbHog1 and the transcription factor AbAP1, were activated in the presence of ICTs. Once activated by ICT-derived ROS, AbAP1 was found to promote the expression of different oxidative-response genes. This response might play a significant role in the protection of the fungus against ICTs as mutants deficient in AbHog1 or AbAP1 were found to be hypersensitive to these metabolites. Moreover, the loss of these genes was accompanied by a significant decrease in aggressiveness on Brassica. We suggest that the robust protection response against ICT-derived oxidative stress might be a key adaptation mechanism for successful infection of host plants by Brassicaceae-specialist necrotrophs like A. brassicicola.
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