Evidence map›Paper›PMID 26089695›Full record

ArticleClinical, cosmetic and investigational dermatology2015

IncobotulinumtoxinA in aesthetics: Russian multidisciplinary expert consensus recommendations.

Yana Yutskovskaya, Elena Gubanova, Irina Khrustaleva, Vasiliy Atamanov, Anastasiya Saybel, Elena Parsagashvili, Irina Dmitrieva, Elena Sanchez, Natalia Lapatina, Tatiana Korolkova and 3 more

Abstract read
In one paragraph

Article in Clinical, cosmetic and investigational dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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  3. Review
  4. Article
  5. Review
  6. Consensus Statement on the Use of Botulinum Neurotoxin in the Middle East.Clinical, cosmetic and investigational dermatology · 2023
    Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yana YutskovskayaDepartment of Dermatovenereology and Cosmetology, Pacific State Medical University, Vladivostock, Russia.
Elena GubanovaDepartment of Skin and Venereal Diseases, Postgraduate Medical Institute, Moscow National University of Food Production, Moscow, Russia.
Irina KhrustalevaDepartment of Plastic Surgery, IP Pavlov Medical State University, St Petersburg, Russia.
Vasiliy AtamanovDepartment of Reconstructive and Plastic Surgery, SN Fedorova, Federal State Institution, Novosibirsk, Russia.
Anastasiya SaybelClinic Ideal, Laser Technologies Center, Moscow, Russia.
Elena ParsagashviliAestima-clinic, St Petersburg, Russia.
Irina DmitrievaClinic "Academy", St Petersburg, Russia.
Elena SanchezEklan Medical Center of Cosmetological Correction, Moscow, Russia.
Natalia LapatinaClinic of Aesthetic Medicine and Plastic Surgery, Moscow, Russia.
Tatiana KorolkovaDepartment of Cosmetology, II Mechnikov North-Western State Medical University, St Petersburg, Russia.
Alena SaromytskayaPlastic Surgery Clinic, Center of Aesthetic Medicine and Beauty Cosmetology, Tyumen, Russia.
Elena Goltsova"Neo-Clinic," Tyumen, Russia.
Elmira SatardinovaBotulinum Toxin Therapy Department, Diagnostic Center of the Irkutsk State Medical Academy of Postgraduate Education, Irkutsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough there are various international consensus recommendations on the use of botulinum neurotoxin type A (BoNT/A) in facial aesthetics, there are no global or Russian guidelines on the optimal dose of incobotulinumtoxinA, free from complexing proteins, within specific aesthetic indications. This article reports the outcomes of two expert consensus meetings, conducted to review and analyze efficacy and tolerability data for incobotulinumtoxinA in various facial aesthetic indications and to give expert consensus recommendations to ensure best clinical practice among Russian clinicians.

methodsThirteen dermatology and/or plastic surgery experts attended meetings held in Paris, France (November 2013), and Moscow, Russia (March 2014). The expert group reviewed and analyzed the existing evidence, consensus recommendations, and Russian experts' extensive practical experience of incobotulinumtoxinA in aesthetics to reach consensus on optimal doses, potential dose adjustments, and injection sites of incobotulinumtoxinA for facial aesthetics.

resultsAll experts developed guidance on the optimal doses for incobotulinumtoxinA treatment of different regions of the upper and lower face. The expert panel agreed that there are no differences in the efficacy and duration of the effect between the four BoNT/As that are commercially available for facial aesthetic indications in Russia and that, when administered correctly, all BoNT/As can achieve optimal results. Experts also agreed that nonresponse to BoNT/A can be caused by neutralizing antibodies.

conclusionOn the basis of the scientific and clinical evidence available for incobotulinumtoxinA, coupled with the extensive clinical experience of the consensus group, experts recommended the optimal doses of incobotulinumtoxinA effective for treatment of wrinkles of the upper and lower face to achieve the expected aesthetic outcome. These first Russian guidelines on the optimal use of incobotulinumtoxinA for augmentation of glabellar lines, periorbital wrinkles, forehead lines, bunny lines, perioral wrinkles, depressor anguli oris, mentalis, masseters and platysmal bands, and performing the Nefertiti lift, are presented here.

Indexed as

aestheticsconsensus guidelinesdosagefacial linesfree from complexing proteinsincobotulinumtoxinARussia

Identifiers

PMID26089695
PMCPMC4467658

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.