ArticleMediators of inflammation2015
A Single Nucleotide Polymorphism (rs4236480) in TRPV5 Calcium Channel Gene Is Associated with Stone Multiplicity in Calcium Nephrolithiasis Patients.
Article in Mediators of inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Genetic polymorphisms as prognostic factors for recurrent kidney stones: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Article
- A successful conclusion to the long search for TRPV5 pathogenic variants in monogenic hypercalciuria.European journal of human genetics : EJHG · 2024Article
- Decreased calcium permeability caused by biallelic TRPV5 mutation leads to autosomal recessive renal calcium-wasting hypercalciuria.European journal of human genetics : EJHG · 2024Article
- The evolving landscape of monogenic nephrolithiasis and therapeutic innovations.Nature reviews. Urology · 2024Review
- Effects of Klotho protein, vitamin D, and oxidative stress parameters on urinary stone formation and recurrence.International urology and nephrology · 2024Article
- Two-way Road of Kidney and Hypercalcemia: A Narrative Review.Cardiovascular & hematological disorders drug targets · 2023Review
- Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms.Frontiers in molecular neuroscience · 2023Review
- Association of TRPV5, CASR, and CALCR genetic variants with kidney stone disease susceptibility in Egyptians through main effects and gene-gene interactions.Urolithiasis · 2022Article
- Molecular mechanisms altering tubular calcium reabsorption.Pediatric nephrology (Berlin, Germany) · 2022Review
- Deep transcriptomic profiling of Dahl salt-sensitive rat kidneys with mutant form of Resp18.Biochemical and biophysical research communications · 2021Article
- Genetics of kidney stone disease.Nature reviews. Urology · 2020Review
- Association of TRPV5 gene polymorphism with calcium urolithiasis: a case-control study from West Bengal, India.World journal of urology · 2020Article
- The rs1256328 (ALPL) and rs12654812 (RGS14) Polymorphisms are Associated with Susceptibility to Calcium Nephrolithiasis in a Taiwanese population.Scientific reports · 2019Article
- Association of sirtuin 1 gene polymorphisms with nephrolithiasis in Eastern chinese population.Renal failure · 2019Article
- Modeling the structural and dynamical changes of the epithelial calcium channel TRPV5 caused by the A563T variation based on the structure of TRPV6.Journal of biomolecular structure & dynamics · 2019Article
- Structural insight into TRPV5 channel function and modulation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Association between single nucleotide polymorphism (rs4252424) in TRPV5 calcium channel gene and lead poisoning in Chinese workers.Molecular genetics & genomic medicine · 2019Article
- The L530R variation associated with recurrent kidney stones impairs the structure and function of TRPV5.Biochemical and biophysical research communications · 2017Article
- Calcium-permeable ion channels in the kidney.American journal of physiology. Renal physiology · 2016Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nephrolithiasis is characterized by calcification of stones in the kidneys from an unknown cause. Animal models demonstrated the functional roles of the transient receptor potential vanilloid member 5 (TRPV5) gene in calcium renal reabsorption and hypercalciuria. Therefore, TRPV5 was suggested to be involved in calcium homeostasis. However, whether genetic polymorphisms of TRPV5 are associated with kidney stone multiplicity or recurrence is unclear. In this study, 365 Taiwanese kidney-stone patients were recruited. Both biochemical data and DNA samples were collected. Genotyping was performed by a TaqMan allelic discrimination assay. We found that a TRPV5 polymorphism (rs4236480) was observed to be associated with stone multiplicity of calcium nephrolithiasis, as the risk of stone multiplicity was higher in patients with the TT+CT genotype than in patients with the CC genotype (p = 0.0271). In summary, despite the complexity of nephrolithiasis and the potential association of numerous calcium homeostatic absorption/reabsorption factors, TRPV5 plays an important role in the pathogenesis of calcium nephrolithiasis.
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