Evidence map›Paper›PMID 26089316›Full record

ArticleAJNR. American journal of neuroradiology2015

Periventricular Location as a Risk Factor for Hemorrhage and Severe Clinical Presentation in Pediatric Patients with Untreated Brain Arteriovenous Malformations.

L Ma, Z Huang, X-L Chen, J Ma, X-J Liu, H Wang, X Ye, S-L Wang, Y Cao, S Wang and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Grades of brain arteriovenous malformations and risk of hemorrhage and death.Annals of clinical and translational neurology · 2019
    Pooled it
  3. Outcomes of Gamma Knife radiosurgery in pediatric arteriovenous malformations: the role of age and lesion characteristics.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Natural history of high-grade pediatric arteriovenous malformations: implications for management options.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020
    Article
  9. Fatal intracranial hemorrhage from brain AVM in a 7-week-old infant: case report and recent literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020
    Review
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

L MaFrom the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.) China National Clinical Research Center for Neurological Diseases (L.M., Z.H., X.-L.C., X.-J.L., Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China.
Z HuangFrom the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.) China National Clinical Research Center for Neurological Diseases (L.M., Z.H., X.-L.C., X.-J.L., Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China.
X-L ChenFrom the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.) China National Clinical Research Center for Neurological Diseases (L.M., Z.H., X.-L.C., X.-J.L., Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China.
J MaNeuroradiology (J.M.), Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China.
X-J LiuFrom the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.) China National Clinical Research Center for Neurological Diseases (L.M., Z.H., X.-L.C., X.-J.L., Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China.
H WangFrom the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.).
X YeFrom the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.).
S-L WangFrom the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.).
Y CaoFrom the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.) China National Clinical Research Center for Neurological Diseases (L.M., Z.H., X.-L.C., X.-J.L., Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease (Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China.
S WangFrom the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.) China National Clinical Research Center for Neurological Diseases (L.M., Z.H., X.-L.C., X.-J.L., Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease (Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China.
Y-L ZhaoFrom the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.) China National Clinical Research Center for Neurological Diseases (L.M., Z.H., X.-L.C., X.-J.L., Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China Center for Stroke (Y.-L.Z., J.-Z.Z.), Beijing Institute for Brain Disorders, Beijing, P. R. China Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease (Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China. zhaoyuanli@126.com.
J-Z ZhaoFrom the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.) China National Clinical Research Center for Neurological Diseases (L.M., Z.H., X.-L.C., X.-J.L., Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China Center for Stroke (Y.-L.Z., J.-Z.Z.), Beijing Institute for Brain Disorders, Beijing, P. R. China Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease (Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China.
National Clinical Research Center for Digestive Diseases · CNChinese Institute for Brain Research · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe morphologic features of brain arteriovenous malformations differ between children and adults; therefore, our aim was to analyze various features of brain arteriovenous malformations to assess the risk of hemorrhage in children. MATERIALS AND

methodsWe identified all consecutive children admitted to Beijing Tiantan Hospital for brain arteriovenous malformations between July 2009 and April 2014. The effects of demographic characteristics and brain arteriovenous malformation morphology on hemorrhage presentation, annual bleeding rates, postnatal hemorrhage, and immediate posthemorrhagic neurologic outcomes were studied by using univariate and multivariable regression analyses.

resultsA total of 108 pediatric brain arteriovenous malformation cases were identified, 66 (61.1%) of which presented with hemorrhage. Of these, 69.7% of ruptured brain arteriovenous malformations were in a periventricular location. Periventricular nidus location (OR, 3.443; 95% CI, 1.328-8.926; P = .011) and nidus size (OR, 0.965; 95% CI, 0.941-0.989; P = .005) were independent predictors of hemorrhagic presentation. The annual hemorrhage rates in children with periventricular brain arteriovenous malformations were higher at 6.88% (OR, 1.965; 95% CI, 1.155-3.341; P < .05). The hemorrhage-free survival rates were also lower for children with periventricular brain arteriovenous malformations (log-rank, P = .01). Periventricular location (hazard ratio, 1.917; 95% CI, 1.131-3.250; P = .016) and nidus size (hazard ratio, 0.983; 95% CI, 0.969-0.997; P = .015) were associated with hemorrhage after birth in pediatric brain arteriovenous malformations. An ordinal analysis showed lower immediate posthemorrhage mRS in patients with periventricular brain arteriovenous malformations (OR for greater disability, 2.71; 95% CI, 1.03-7.11; P = .043).

conclusionsSmall periventricular brain arteriovenous malformations were associated with increased hemorrhage risk in pediatric patients. Cautious follow-up of children with untreated periventricular brain arteriovenous malformations is recommended because of a higher hemorrhage risk and potentially more severe neurologic outcomes.

Indexed as

AdolescentBeijingCerebral HemorrhageChildChild, PreschoolFemaleHumansIncidenceIntracranial Arteriovenous MalformationsMaleRisk FactorsSurvival Rate

Identifiers

PMID26089316
PMCPMC7964676
OpenAlexW2138635624

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.