ArticleNeurorehabilitation and neural repair2016
Cortical Silent Period Reveals Differences Between Adductor Spasmodic Dysphonia and Muscle Tension Dysphonia.
Article in Neurorehabilitation and neural repair, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 35 citations in OpenAlex.
- Connectome-Wide Phenotypical and Genotypical Associations in Focal Dystonia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Trial
- Versatility of Transcranial Magnetic Stimulation: A Review of Diagnostic and Therapeutic Applications.Brain sciences · 2026Review
- Spasmodic Dysphonia.World journal of otorhinolaryngology - head and neck surgery · 2025Review
- Review
- Lombard Effect in Individuals With Nonphonotraumatic Vocal Hyperfunction: Impact on Acoustic, Aerodynamic, and Vocal Fold Vibratory Parameters.Journal of speech, language, and hearing research : JSLHR · 2022Article
- Integrative Review and Framework of Suggested Mechanisms in Primary Muscle Tension Dysphonia.Journal of speech, language, and hearing research : JSLHR · 2022Review
- Effects of low-frequency repetitive transcranial magnetic stimulation in adductor laryngeal dystonia: a safety, feasibility, and pilot study.Experimental brain research · 2022Article
- Temporal specificity of abnormal neural oscillations during phonatory events in laryngeal dystonia.Brain communications · 2022Article
- The effects of continuous oromotor activity on speech motor learning: speech biomechanics and neurophysiologic correlates.Experimental brain research · 2021Article
- Laryngeal Dystonia: Multidisciplinary Update on Terminology, Pathophysiology, and Research Priorities.Neurology · 2021Review
- An Updated Theoretical Framework for Vocal Hyperfunction.American journal of speech-language pathology · 2020Article
- Hyperactive sensorimotor cortex during voice perception in spasmodic dysphonia.Scientific reports · 2020Article
- Evidence for normal intracortical inhibitory recruitment properties in cervical dystonia.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2020Article
- Defining research priorities in dystonia.Neurology · 2020Review
- Cortical sensorimotor alterations classify clinical phenotype and putative genotype of spasmodic dysphonia.European journal of neurology · 2016Article
- Transcranial magnetic stimulation and functional magnet resonance imaging evaluation of adductor spasmodic dysphonia during phonation.Brain stimulationArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe pathophysiology of adductor spasmodic dysphonia (AdSD), like other focal dystonias, is largely unknown.
objectiveThe purposes of this study were to determine (a) cortical excitability differences between AdSD, muscle tension dysphonia (MTD), and healthy controls; (b) distribution of potential differences in cranial or skeletal muscle; and (c) if cortical excitability measures assist in the differential diagnosis of AdSD and MTD.
methodsTen participants with adductor spasmodic dysphonia, 8 with muscle tension dysphonia, and 10 healthy controls received single and paired pulse transcranial magnetic stimulation (TMS) to the primary motor cortex contralateral to tested muscles, first dorsal interosseus (FDI), and masseter. We tested the hypothesis that cortical excitability measures in AdSD would be significantly different from those in MTD and healthy controls. In addition, we hypothesized that there would be a correlation between cortical excitability measures and clinical voice severity in AdSD.
resultsCortical silent period duration in masseter and FDI was significantly shorter in AdSD than MTD and healthy controls. Other measures failed to demonstrate differences.
conclusionThere are differences in cortical excitability between AdSD, MTD, and healthy controls. These differences in the cortical measure of both the FDI and masseter muscles in AdSD suggest widespread dysfunction of the GABAB mechanism may be a pathophysiologic feature of AdSD, similar to other forms of focal dystonia. Further exploration of the use of TMS to assist in the differential diagnosis of AdSD and MTD is warranted.
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