Evidence map›Paper›PMID 26088659›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2015

Pharmacotherapy of the Preschool ADHD Treatment Study (PATS) Children Growing Up.

Benedetto Vitiello, Deborah Lazzaretto, Kseniya Yershova, Howard Abikoff, Natalya Paykina, James T McCracken, James J McGough, Scott H Kollins, Laurence L Greenhill, Sharon Wigal and 2 more

Open access · greenAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Effectiveness of Stimulant Medications on Disruptive Behavior and Mood Problems in Young Children.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2020
    Article
  7. Review
  8. Time to Stable Dose of Psychostimulants in Pediatric Patients With ADHD.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2020
    Article
  9. Article
  10. ADHD Treatment in Primary Care: Demographic Factors, Medication Trends, and Treatment Predictors.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Benedetto VitielloNational Institute of Mental Health (NIMH), Bethesda, MD. Electronic address: bvitiell@nih.gov.
Deborah Lazzarettoindependent statistical contractor.
Kseniya YershovaColumbia University Medical Center and New York State Psychiatric Institute (NYSPI), New York.
Howard AbikoffNew York University School of Medicine, New York.
Natalya PaykinaColumbia University Medical Center and New York State Psychiatric Institute (NYSPI), New York.
James T McCrackenUniversity of California, Los Angeles.
James J McGoughUniversity of California, Los Angeles.
Scott H KollinsDuke University School of Medicine, Durham, NC.
Laurence L GreenhillColumbia University Medical Center and New York State Psychiatric Institute (NYSPI), New York.
Sharon WigalUniversity of California, Irvine when this work was conducted and now are with AVIDA Inc., Newport Beach, CA.
Tim WigalUniversity of California, Irvine when this work was conducted and now are with AVIDA Inc., Newport Beach, CA.
Mark A RiddleJohns Hopkins University School of Medicine, Baltimore.
Columbia University Irving Medical Center · USUniversity of California, Irvine · USUniversity of California, Los Angeles · USDuke University · USIndependent Sector · USJohns Hopkins University · USNational Institute of Mental Health · USNew York University · US

Funding

METHYLPHENIDATE EFFICACY AND SAFETY IN ADHD PRESCHOOLERSU01MH060903 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI GREENHILL, LARRY LEE · 2000 to 2008
$3.1M
METHYLPHENIDATE EFFICACY AND SAFETY IN ADHD PRESCHOOLERSU01MH060833 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI WIGAL, TIMOTHY L · 2000 to 2008
$2.4M
The Follow-Up of the PATS SampleU01MH060943 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ABIKOFF, HOWARD BARRY · 2000 to 2008
$1.9M
METHYLPHENIDATE EFFICACY AND SAFETY IN ADHD PRESCHOOLERSU01MH060848 · NIMH · DUKE UNIVERSITY · PI KOLLINS, SCOTT H · 2000 to 2008
$1.7M
METHYLPHENIDATE EFFICACY AND SAFETY IN ADHD PRESCHOOLERSU01MH060900 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2000 to 2008
$1.5M
METHYLPHENIDATE EFFICACY AND SAFETY IN ADHD PRESCHOOLERSU01MH060642 · NIMH · JOHNS HOPKINS UNIVERSITY · PI RIDDLE, MARK A · 2000 to 2008
$1.5M
Intramural NIH HHS Z99 MH999999NIMH NIH HHS U01 MH060642NIMH NIH HHS U01 MH060833NIMH NIH HHS U01 MH060848NIMH NIH HHS U01 MH060900NIMH NIH HHS U01 MH060903NIMH NIH HHS U01 MH060943NIMH NIH HHS U01 MH60642NIMH NIH HHS U01 MH60833NIMH NIH HHS U01MH60848NIMH NIH HHS U01 MH60900NIMH NIH HHS U01 MH60903NIMH NIH HHS U01 MH60943
6 · The paper itself

Abstract

objectiveTo describe the long-term psychopharmacological treatment of children first diagnosed with attention-deficit/hyperactivity disorder (ADHD) as preschoolers.

methodIn a systematic, prospective, naturalistic follow-up, 206 (68.0%) of the 303 children who participated in the Preschool ADHD Treatment Study (PATS) were reassessed 3 years (mean age 7.4 years) and 179 (59.1%) were reassessed 6 years (mean age 10.4 years) after completion of the controlled study. Pharmacotherapy and clinical data were obtained from the parents. Pharmacotherapy was defined as use of a specific class of medication for at least 50% of the days in the previous 6 months.

resultsAt year 3, a total of 34.0% of the participants were on no pharmacotherapy, 41.3% were on stimulant monotherapy, 9.2% were on atomoxetine alone or with a stimulant, 8.3% were on an antipsychotic usually together with a stimulant, and the remaining 7.2% were on other pharmacotherapy; overall, 65.0% were on an indicated ADHD medication. At year 6, a total of 26.8% of the participants were on no pharmacotherapy, 40.2% were on stimulant monotherapy, 4.5% were on atomoxetine alone or with a stimulant, 13.4% were on an antipsychotic, and 15.1% were on other pharmacotherapy; overall, 70.9% were on an indicated ADHD medication. Antipsychotic treatment was associated with more comorbidity, in particular disruptive behavior disorders and pervasive development disorders, and a lower level of functioning.

conclusionIn this study, the long-term pharmacotherapy of preschoolers with ADHD was heterogeneous. Although stimulant medication continued to be used by most children, about 1 child in 4 was off medication, and about 1 in 10 was on an antipsychotic.

Indexed as

Antipsychotic AgentsAtomoxetine HydrochlorideAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsChildChild, PreschoolComorbidityFemaleFollow-Up StudiesHumansLogistic ModelsMaleMethylphenidateProspective StudiesPsychiatric Status Rating ScalesTreatment OutcomeAntipsychotic AgentsAtomoxetine HydrochlorideCentral Nervous System StimulantsMethylphenidateADHDmedicationpreschoolersstimulant

Identifiers

PMID26088659
PMCPMC4475273
OpenAlexW2158545381

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.