Trial reportJournal of feline medicine and surgery2016
Effects of ketamine and alfaxalone on application of a feline pain assessment scale.
Trial report in Journal of feline medicine and surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Characterization of pain behaviors in kittens following ovariohysterectomy using video assessment.Scientific reports · 2025Article
- Effect of surgical simulator training on student and live animal outcomes in a feline ovariohysterectomy teaching laboratory.Veterinary surgery : VS · 2024Article
- Post-anesthetic CPS and EQUUS-FAP scores in surgical and non-surgical equine patients: an observational study.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- 2022 ISFM Consensus Guidelines on the Management of Acute Pain in Cats.Journal of feline medicine and surgery · 2022Article
- Development and Testing of a Sedation Scale for Use in Rabbits (Journal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
- Clinical validation of the short and long UNESP-Botucatu scales for feline pain assessment.PeerJ · 2021Article
- Anesthetic Effects of Intramuscular Alfaxalone-Ketamine in Naked Mole Rats (Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- A randomized clinical trial comparing butorphanol and buprenorphine within a multimodal analgesic protocol in cats undergoing orchiectomy.Journal of feline medicine and surgery · 2020Article
- Anesthetic and analgesic effects of an opioid-free, injectable protocol in cats undergoing ovariohysterectomy: A prospective, blinded, randomized clinical trial.The Canadian veterinary journal = La revue veterinaire canadienne · 2020Article
- Prevalence and management of pain in dogs in the emergency service of a veterinary teaching hospital.The Canadian veterinary journal = La revue veterinaire canadienne · 2020Article
- Postoperative pain behaviours in rabbits following orthopaedic surgery and effect of observer presence.PloS one · 2020Article
- Article
- Facial expressions of pain in cats: the development and validation of a Feline Grimace Scale.Scientific reports · 2019Article
- Acute pain in cats: Recent advances in clinical assessment.Journal of feline medicine and surgery · 2019Review
- Assessing analgesia equivalence and appetite following alfaxalone- or ketamine-based injectable anesthesia for feline castration as an example of enhanced recovery after surgery.Journal of feline medicine and surgery · 2018Article
- Sedation levels in dogs: a validation study.BMC veterinary research · 2017Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe objective of this study was to compare the effects of ketamine and alfaxalone on the application of a validated feline-specific multidimensional composite pain scale (UNESP-Botucatu MCPS).
methodsIn a prospective, randomized, blinded, crossover trial, 11 adult cats (weight 4.4 ± 0.6 kg) were given dexmedetomidine (15 μg/kg) and hydromorphone (0.05 mg/kg) with either alfaxalone (2 mg/kg) or ketamine (5 mg/kg) as a single intramuscular injection for the induction of general anesthesia. After orotracheal intubation, general anesthesia (without surgery) was maintained for 32 mins with isoflurane, followed by atipamezole. The following parameters were recorded at baseline, 1-8 h and 24 h post-extubation: pain (pain expression and psychomotor subscales) and sedation scale scores. Alfaxalone treatment injection sites were examined for inflammation at baseline, postinjection, and 8 h and 24 h post-extubation.
resultsPsychomotor scores were higher with ketamine at hours 1 (3.5 [0-5.0], P <0.0001), 2 (2.5 [0-4.0], P <0.0001) and 3 (0.5 [0-4.0], P = 0.009) post-extubation compared with alfaxalone (hour 1, 0 [0-2]; hour 2, 0 [0-0]; hour 3, 0 [0-0]). Six cats in the ketamine group crossed the analgesic intervention threshold. In contrast, pain expression scores did not differ significantly between treatments at any time (P >0.05); one cat from each group crossed the analgesic intervention threshold. Sedation was greater with ketamine (1 [0-3], P = 0.02) than alfaxalone (0 [0-1]) 1 h post-extubation. No cats had visible inflammation at the injection sites at any time. CONCLUSIONS AND RELEVANCE: Ketamine has a confounding effect on the psychomotor subscale of the pain scale studied, which may lead to erroneous administration of rescue analgesia. In contrast, alfaxalone was not associated with significant increases in either pain subscale. These effects of ketamine should be considered when evaluating acute postoperative pain in cats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.