Evidence map›Paper›PMID 26088468›Full record

ArticleLa Radiologia medica2015

Low-dose gadobenate dimeglumine-enhanced MRI of the kidney for the differential diagnosis of localized renal lesions.

Guenther Schneider, Thorsten Probst, Miles A Kirchin, Jonas Stroeder, Peter Fries, Arno Buecker

Open access · hybridAbstract read
In one paragraph

Article in La Radiologia medica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Guenther SchneiderDepartment of Diagnostic and Interventional Radiology, Saarland University Medical Center, 66421, Homburg/Saar, Germany. dr.guenther.schneider@uks.eu.
Thorsten ProbstDepartment of Diagnostic and Interventional Radiology, Saarland University Medical Center, 66421, Homburg/Saar, Germany.
Miles A KirchinGlobal Medical and Regulatory Affairs, Bracco Imaging SpA, Milan, Italy. miles.kirchin@bracco.com.
Jonas StroederDepartment of Diagnostic and Interventional Radiology, Saarland University Medical Center, 66421, Homburg/Saar, Germany.
Peter FriesDepartment of Diagnostic and Interventional Radiology, Saarland University Medical Center, 66421, Homburg/Saar, Germany.
Arno BueckerDepartment of Diagnostic and Interventional Radiology, Saarland University Medical Center, 66421, Homburg/Saar, Germany.
Saarland University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate low-dose gadobenate dimeglumine-enhanced MRI for the differential diagnosis of malignant renal tumors.

methodsSixty-two consecutive patients with unclear diagnosis at MDCT/ultrasound underwent dynamic CE-MRI of the kidneys with 0.05 mmol/kg gadobenate dimeglumine. Retrospective image evaluation was performed by two blinded readers. Lesion diagnosis at CE-MRI was correlated with findings from histology following tumor resection or from imaging follow-up after at least 1 year. Assessments were performed of diagnostic quality and level of diagnostic information.

resultsThirty-nine (63 %) patients were correctly diagnosed with malignant lesions (36 with RCC, 2 with renal metastases, 1 with lymphoma) while 14 (22.6 %) patients were correctly diagnosed with benign (n = 12) or no (n = 2) lesions. Eight patients were considered false positive (5 with oncocytoma, 3 with atypical AML) and 1 patient false negative (atypical RCC). The sensitivity, specificity, accuracy, PPV, and NPV for the diagnosis of malignant renal lesions were 97.5 % (39/40), 63.6 % (14/22), 85.5 % (53/62), 83.0 % (39/47), and 93.3 % (14/15), respectively. Images were excellent in 60 and good in 2 patients. Minimal artifacts that did not compromise diagnosis were noted in 4/62 patients.

conclusionLow-dose gadobenate dimeglumine-enhanced MRI is effective for the differential diagnosis of malignant renal tumors.

Indexed as

AdolescentAdultAgedArtifactsCarcinoma, Renal CellChildContrast MediaDiagnosis, DifferentialFalse Negative ReactionsFalse Positive ReactionsFemaleHumansKidneyKidney NeoplasmsLymphomaMagnetic Resonance ImagingContrast Mediagadobenic acidMeglumineOrganometallic CompoundsGadobenate dimeglumineKidneyRenal cell carcinomaRenal MRI

Identifiers

PMID26088468
PMCPMC4646924
OpenAlexW617428596

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.