Evidence map›Paper›PMID 26088297›Full record

ArticleCancer gene therapy2015

Color-coding cancer and stromal cells with genetic reporters in a patient-derived orthotopic xenograft (PDOX) model of pancreatic cancer enhances fluorescence-guided surgery.

S Yano, Y Hiroshima, A Maawy, H Kishimoto, A Suetsugu, S Miwa, M Toneri, M Yamamoto, M H G Katz, J B Fleming and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer gene therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 53 citations in OpenAlex.

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  15. Patient-derived xenografts: a relevant preclinical model for drug development.Journal of experimental & clinical cancer research : CR · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

S Yano1] AntiCancer, San Diego, CA, USA [2] Department of Surgery, University of California San Diego, San Diego, CA, USA [3] Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Y Hiroshima1] AntiCancer, San Diego, CA, USA [2] Department of Surgery, University of California San Diego, San Diego, CA, USA.
A MaawyDepartment of Surgery, University of California San Diego, San Diego, CA, USA.
H KishimotoDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
A SuetsuguDepartment of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, Japan.
S Miwa1] AntiCancer, San Diego, CA, USA [2] Department of Surgery, University of California San Diego, San Diego, CA, USA.
M Toneri1] AntiCancer, San Diego, CA, USA [2] Department of Surgery, University of California San Diego, San Diego, CA, USA.
M Yamamoto1] AntiCancer, San Diego, CA, USA [2] Department of Surgery, University of California San Diego, San Diego, CA, USA.
M H G KatzDepartment of Surgical Oncoloy, MD Anderson Cancer Center, University of Texas, Houston, TX, USA.
J B FlemingDepartment of Surgical Oncoloy, MD Anderson Cancer Center, University of Texas, Houston, TX, USA.
Y UrataOncolys BioPharm, Tokyo, Japan.
H TazawaCenter for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan.
S KagawaDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
M BouvetDepartment of Surgery, University of California San Diego, San Diego, CA, USA.
T FujiwaraDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
R M Hoffman1] AntiCancer, San Diego, CA, USA [2] Department of Surgery, University of California San Diego, San Diego, CA, USA.
Okayama University · JPThe University of Texas MD Anderson Cancer Center · USUniversity of California, San Diego · USGifu University · JPOkayama University Hospital · JPOncolys BioPharma (Japan) · JP

Funding

Fluorophore-Conjugated Antibodies for Imaging and Resection of GI TumorsR01CA142669 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOUVET, MICHAEL, YANG, MENG · 2010 to 2015
$1.7M
Color-Coded Imaging of Pancreatic Cancer Microenvironment for Drug DiscoveryR01CA132971 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOUVET, MICHAEL, YANG, MENG · 2009 to 2013
$1.7M
NCI NIH HHS CA132971NCI NIH HHS CA142669NCI NIH HHS R01 CA142669
6 · The paper itself

Abstract

Precise fluorescence-guided surgery (FGS) for pancreatic cancer has the potential to greatly improve the outcome in this recalcitrant disease. To achieve this goal, we have used genetic reporters to color code cancer and stroma cells in a patient-derived orthotopic xenograft (PDOX) model. The telomerase-dependent green fluorescent protein (GFP)-containing adenovirus OBP-401 was used to label the cancer cells of a pancreatic cancer PDOX. The PDOX was previously grown in a red fluorescent protein (RFP) transgenic mouse that stably labeled the PDOX stroma cells bright red. The color-coded PDOX model enabled FGS to completely resect the pancreatic tumors including stroma. Dual-colored FGS significantly prevented local recurrence, which bright-light surgery or single-color FGS could not. FGS, with color-coded cancer and stroma cells has important potential for improving the outcome of recalcitrant-cancer surgery.

Indexed as

Surgery, Computer-AssistedAnimalsGenes, ReporterGreen Fluorescent ProteinsLuminescent ProteinsMice, NudeMice, TransgenicNeoplasm Recurrence, LocalNeoplasm TransplantationPancreatic NeoplasmsRed Fluorescent ProteinGreen Fluorescent ProteinsLuminescent ProteinsRed Fluorescent Protein

Identifiers

PMID26088297
PMCPMC4523223
OpenAlexW1602965390

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.