ReviewCurrent rheumatology reviews2015
Programmed symptoms: disparate effects united by purpose.
Review in Current rheumatology reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- A life-stress, emotional awareness, and expression interview for primary care patients with medically unexplained symptoms: A randomized controlled trial.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2018Trial
- Trial
- A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment.Journal of pain research · 2025Review
- Fatigue, interoplastic and nociplastic distress in myalgic encephalomyelitis/chronic fatigue syndrome, Gulf War Illness, and chronic idiopathic fatigue.Frontiers in neuroscience · 2025Article
- Understanding the clinical profile of patients with frozen shoulder: a longitudinal multicentre observational study.BMJ open · 2022Observational
- Slowly repeated evoked pain (SREP) as a central sensitization marker in episodic migraine patients.Scientific reports · 2021Article
- Persistent dentoalveolar pain disorder: A putative intraoral chronic overlapping pain condition.Oral diseases · 2020Review
- Neuropathic Itch.Cells · 2020Review
- Systemic Hyperalgesia in Females with Gulf War Illness, Chronic Fatigue Syndrome and Fibromyalgia.Scientific reports · 2020Article
- Itch Processing in the Skin.Frontiers in medicine · 2019Review
- How Accurate Appraisal of Behavioral Costs and Benefits Guides Adaptive Pain Coping.Frontiers in psychiatry · 2017Review
- Attachment and Chronic Pain in Children and Adolescents.Children (Basel, Switzerland) · 2016Review
- Overlapping Chronic Pain Conditions: Implications for Diagnosis and Classification.The journal of pain · 2016Review
- Psychological Therapy for Centralized Pain: An Integrative Assessment and Treatment Model.Psychosomatic medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Central sensitivity syndromes (CSS) share features of similar multiple symptoms, virtually unknown mechanisms and lack of effective treatments. The CSS nomenclature was chosen over alternatives because it focused on a putative physiological mechanism of central sensitization common to disorders such as fibromyalgia, irritable bowel syndrome, vulvodynia and temporomandibular disorder. Increasing evidence from multiple biological systems suggests a further development. In this new model central sensitization is part of a ensemble that includes also the symptoms of widespread pain, fatigue, unrefreshing sleep and dyscognition. The main feature is an intrinsic program that produces this ensemble to guide behavior to restore normal function in conditions that threaten survival. The well known "illness response" is a classic example that is triggered in response to the specific threat of viral infection. The major leap for this model in the context of CSS is that the symptom complex is not a reactive result of pathology, but a purposeful feeling state enlisted to combat pathology. Once triggered, this state is produced by potential mechanisms that likely include contributions of the peripheral and central immune systems, as well as stress response systems such as the autonomic system and the hypothalamic-pituitary-adrenal (HPA) axis. These act in concert to alter behavior in a beneficial direction. This concept explains similar symptoms for many triggering conditions, the poorly understood pathology, and the resistance to treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.