Evidence map›Paper›PMID 26087681›Full record

ReviewNature reviews. Neuroscience2015

The neuroscience of placebo effects: connecting context, learning and health.

Tor D Wager, Lauren Y Atlas

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03294148 (Mind-body Treatments for Chronic Back Pain), which is not on this map. Cited by 400 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
400citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03294148 nacompletednot on this mapstarted 2017, after this paper: background citation

Mind-body Treatments for Chronic Back Pain

TypeinterventionalSponsorUniversity of Colorado, BoulderRan2017 to 2019Enrolled151ConditionsChronic Pain, Back Pain Lower Back Chronic, Back Pain, LowArmsOpen-Label Placebo Treatment for Chronic Back Pain, Psychotherapy Treatment for Chronic Back Pain
3 · Its place in the literature

Who cites it

400 citing papers in PubMed, 18 syntheses or guidelines pooled it.

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  13. The Nocebo Effect: A Review of Contemporary Experimental Research.International journal of behavioral medicine · 2022
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340 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tor D WagerDepartment of Psychology and Neuroscience, University of Colorado, Boulder, 345 UCB, Boulder, Colorado 80309, USA.
Lauren Y AtlasNational Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, Maryland 20982, USA.

Funding

The Neural Bases of Placebo Effects and their Relation to Regulatory ProcessesR01MH076136 · NIMH · UNIVERSITY OF COLORADO · PI WAGER, TOR D. · 2007 to 2023
$8.5M
Neural and psychological mechanisms of pain perception ZIAAT000030 · NCCIH · NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH · PI ATLAS, LAUREN · 2015 to 2025
$3.8M
Learning to avoid pain: Computational mechanisms and application to methamphetamiR01DA027794 · NIDA · UNIVERSITY OF COLORADO · PI WAGER, TOR D. · 2009 to 2013
$1.7M
Intramural NIH HHSNIDA NIH HHS R01 DA027794NIDA NIH HHS R01DA027794NIMH NIH HHS 2R01MH076136NIMH NIH HHS R01 MH076136
6 · The paper itself

Abstract

Placebo effects are beneficial effects that are attributable to the brain-mind responses to the context in which a treatment is delivered rather than to the specific actions of the drug. They are mediated by diverse processes--including learning, expectations and social cognition--and can influence various clinical and physiological outcomes related to health. Emerging neuroscience evidence implicates multiple brain systems and neurochemical mediators, including opioids and dopamine. We present an empirical review of the brain systems that are involved in placebo effects, focusing on placebo analgesia, and a conceptual framework linking these findings to the mind-brain processes that mediate them. This framework suggests that the neuropsychological processes that mediate placebo effects may be crucial for a wide array of therapeutic approaches, including many drugs.

Indexed as

Placebo EffectBrainHumansLearningMental ProcessesNeural PathwaysNeurosciencesPain Management

Identifiers

PMID26087681
PMCPMC6013051

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.