ArticleExperimental gerontology2015
Gene expression markers of age-related inflammation in two human cohorts.
Article in Experimental gerontology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- The role of IL-33/ST2 signaling in female reproductive diseases.Frontiers in cell and developmental biology · 2026Review
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- Analysis of immunogenic cell death in periodontitis based on scRNA-seq and bulk RNA-seq data.Frontiers in immunology · 2024Article
- Potential Theranostic Roles of SLC4 Molecules in Human Diseases.International journal of molecular sciences · 2023Review
- Heart failure with preserved ejection fraction and non-alcoholic fatty liver disease: new insights from bioinformatics.ESC heart failure · 2023Article
- Biological aging processes underlying cognitive decline and neurodegenerative disease.The Journal of clinical investigation · 2022Review
- Inflammation and Cardiovascular Diseases in the Elderly: The Role of Epicardial Adipose Tissue.Frontiers in medicine · 2022Review
- Methods for Characterization of Senescent Circulating and Tumor-Infiltrating T-Cells: An Overview from Multicolor Flow Cytometry to Single-Cell RNA Sequencing.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Objectively Measured Physical Activity in Asymptomatic Middle-Aged Men Is Associated With Routine Blood-Based Biomarkers.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Expression, Localization, and Effect of High Salt Intake on Electroneutral NaFrontiers in physiology · 2019Article
- Peripheral Maintenance of the Axis SIRT1-SIRT3 at Youth Level May Contribute to Brain Resilience in Middle-Aged Amateur Rugby Players.Frontiers in aging neuroscience · 2019Article
- The RNA world of human ageing.Human genetics · 2018Review
- Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty.Nature reviews. Cardiology · 2018Review
- Aging, inflammation and the environment.Experimental gerontology · 2018Review
- Human T cell immunosenescence and inflammation in aging.Journal of leukocyte biology · 2017Review
- Cross-sectional relations of whole-blood miRNA expression levels and hand grip strength in a community sample.Aging cell · 2017Article
- Stability of pro- and anti-inflammatory immune biomarkers for human cohort studies.Journal of translational medicine · 2017Article
- Host Resistance and Immune Aging.Clinics in geriatric medicine · 2016Review
- Trajectories of function and biomarkers with age: the CHS All Stars Study.International journal of epidemiology · 2016Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 2 countries.
Funding
Abstract
introductionChronically elevated circulating inflammatory markers are common in older persons but mechanisms are unclear. Many blood transcripts (>800 genes) are associated with interleukin-6 protein levels (IL6) independent of age. We aimed to identify gene transcripts statistically mediating, as drivers or responders, the increasing levels of IL6 protein in blood at older ages.
methodsBlood derived in-vivo RNA from the Framingham Heart Study (FHS, n=2422, ages 40-92 yrs) and InCHIANTI study (n=694, ages 30-104 yrs), with Affymetrix and Illumina expression arrays respectively (>17,000 genes tested), were tested for statistical mediation of the age-IL6 association using resampling techniques, adjusted for confounders and multiple testing.
resultsIn FHS, IL6 expression was not associated with IL6 protein levels in blood. 102 genes (0.6% of 17,324 expressed) statistically mediated the age-IL6 association of which 25 replicated in InCHIANTI (including 5 of the 10 largest effect genes). The largest effect gene (SLC4A10, coding for NCBE, a sodium bicarbonate transporter) mediated 19% (adjusted CI 8.9 to 34.1%) and replicated by PCR in InCHIANTI (n=194, 35.6% mediated, p=0.01). Other replicated mediators included PRF1 (perforin, a cytolytic protein in cytotoxic T lymphocytes and NK cells) and IL1B (Interleukin 1 beta): few other cytokines were significant mediators.
conclusionsThis transcriptome-wide study on human blood identified a small distinct set of genes that statistically mediate the age-IL6 association. Findings are robust across two cohorts and different expression technologies. Raised IL6 levels may not derive from circulating white cells in age related inflammation.
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