ArticlePloS one2015
Role of SFP1 in the Regulation of Candida albicans Biofilm Formation.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- V-ATPase contributes to the cariogenicity of Candida albicans- Streptococcus mutans biofilm.NPJ biofilms and microbiomes · 2025Article
- Transcriptional profiling reveals the role of Candida albicans Rap1 in oxidative stress response.Bioscience reports · 2024Article
- Molecular Determinants Involved in Candida albicans Biofilm Formation and Regulation.Molecular biotechnology · 2024Review
- Fungal biofilm formation and its regulatory mechanism.Heliyon · 2024Review
- Associations of Rap1 with Cell Wall Integrity, Biofilm Formation, and Virulence in Candida albicans.Microbiology spectrum · 2022Article
- The Role of Sfp1 inJournal of fungi (Basel, Switzerland) · 2022Article
- Synergistic Antibiofilm Effects of Pseudolaric Acid A Combined with Fluconazole against Candida albicans via Inhibition of Adhesion and Yeast-To-Hypha Transition.Microbiology spectrum · 2022Article
- Regulatory network controls microbial biofilm development, withBioengineered · 2022Review
- Article
- Antimicrobial Activity of the Peptide LfcinB15 againstJournal of fungi (Basel, Switzerland) · 2021Article
- Article
- Transcriptional Circuits Regulating Developmental Processes inFrontiers in cellular and infection microbiology · 2020Review
- The Transcription Factor Sfp1 Regulates the Oxidative Stress Response inMicroorganisms · 2019Article
- Investigating Common Pathogenic Mechanisms betweenToxins · 2019Article
- Lycorine Hydrochloride Inhibits the Virulence Traits ofBioMed research international · 2019Article
- Development and regulation of single- and multi-species Candida albicans biofilms.Nature reviews. Microbiology · 2018Review
- Sfp1 and Rtg3 reciprocally modulate carbon source-conditional stress adaptation in the pathogenic yeast Candida albicans.Molecular microbiology · 2017Article
- The Antimicrobial Peptides P-113Du and P-113Tri Function against Candida albicans.Antimicrobial agents and chemotherapy · 2016Article
- Microbial Biofilms in Pulmonary and Critical Care Diseases.Annals of the American Thoracic Society · 2016Review
- Anticandidal Effect and Mechanisms of Monoterpenoid, Perillyl Alcohol against Candida albicans.PloS one · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Candida albicans is a major human fungal pathogen. One of the important features of C. albicans pathogenicity is the ability to form biofilms on mucosal surfaces and indwelling medical devices. Biofilm formation involves complex processes in C. albicans, including cell adhesion, filamentous growth, extracellular matrix secretion and cell dispersion. In this work, we characterized the role of the transcription factor Sfp1, particularly with respect to its function in the regulation of biofilm formation. The deletion of the SFP1 gene enhanced cell adhesion and biofilm formation in comparison to the wild-type strain. Interestingly, the sfp1-deleted mutant also exhibited an increase in the expression of the ALS1, ALS3 and HWP1 genes, which encode adhesin proteins. In addition, Sfp1 was demonstrated to function downstream of the Rhb1-TOR signaling pathway. Bcr1 and Efg1 are transcription factors that are critical for controlling biofilm formation, and Efg1 is also required for hyphal growth. Deleting either the BCR1 or EFG1 gene in the sfp1-null background led to reduced adhesin gene expression. As a result, the bcr1/sfp1 or efg1/sfp1 double deletion mutants exhibited dramatically reduced biofilm formation. The results indicated that Sfp1 negatively regulates the ALS1, ALS3 and HWP1 adhesin genes and that the repression of these genes is mediated by the inhibition of Bcr1 and Efg1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.