Trial reportChest2015
School Endotoxin Exposure and Asthma Morbidity in Inner-city Children.
Trial report in Chest, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01756391 (Allergens in Inner-City Schools and Childhood Asthma), which is not on this map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Allergens in Inner-City Schools and Childhood Asthma
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Association of indoor microbial aerosols with respiratory symptoms among under-five children: a systematic review and meta-analysis.Environmental health : a global access science source · 2021Pooled it
- Respiratory health effects of exposure to low levels of airborne endotoxin - a systematic review.Environmental health : a global access science source · 2018Pooled it
- Proximity to major roadways and asthma symptoms in the School Inner-City Asthma Study.The Journal of allergy and clinical immunology · 2020Trial
- The classroom microbiome and asthma morbidity in children attending 3 inner-city schools.The Journal of allergy and clinical immunology · 2018Trial
- Gamma tocopherol-enriched supplement reduces sputum eosinophilia and endotoxin-induced sputum neutrophilia in volunteers with asthma.The Journal of allergy and clinical immunology · 2018Trial
- Gene-environment interaction between an IL4R variant and school endotoxin exposure contributes to asthma symptoms in inner-city children.The Journal of allergy and clinical immunology · 2018Trial
- The School Inner-City Asthma Intervention Study: Design, rationale, methods, and lessons learned.Contemporary clinical trials · 2017Trial
- Classroom microbiome signatures of pest management associate with reduced asthma symptoms.The Journal of allergy and clinical immunology · 2026Article
- Shape of the association between endotoxin in school dust and children's lung function.ERJ open research · 2025Article
- Comparative analysis of ambient, in-home, and personal exposures reveals associations between breathing zone pollutant levels and asthma exacerbations in high-risk children.Respiratory research · 2025Article
- Recommendations for Clinicians to Combat Environmental Disparities in Pediatric Asthma: A Review.Chest · 2024Review
- Early life exposures of childhood asthma and allergies-an epidemiologic perspective.Frontiers in allergy · 2024Article
- Effect of radon exposure on asthma morbidity in the School Inner-City Asthma study.Pediatric pulmonology · 2023Article
- Innovative compounds to reduce β-D-glucans, endotoxin, and allergens newly discovered on smartphones.The journal of allergy and clinical immunology. Global · 2023Article
- Environmental radon and childhood asthma.Pediatric pulmonology · 2022Article
- The influence of urban exposures and residence on childhood asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Review
- Comparing the concentration levels of allergens and endotoxins in employees' homes and offices.International archives of occupational and environmental health · 2022Article
- Associations of Snoring and Asthma Morbidity in the School Inner-City Asthma Study.The journal of allergy and clinical immunology. In practice · 2021Article
- Air quality, Environment and Respiratory Outcomes in Bronchopulmonary Dysplasia, the AERO-BPD cohort study: design and adaptation during the SARS-CoV-2 pandemic.BMJ open respiratory research · 2021Article
- Indoor Microbial Exposures and Chronic Lung Disease: From Microbial Toxins to the Microbiome.Clinics in chest medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundEndotoxin exposure is associated with airway inflammation. Children spend 6 to 8 h/d in school, yet the effect of school-specific endotoxin exposure on asthma morbidity is not well understood.
methodsIn this longitudinal cohort study, 248 students with asthma, from 38 inner-city schools, underwent baseline phenotyping and follow-up. Clinical outcomes were evaluated throughout the academic school year and linked to classroom-specific dust and air endotoxin levels as well as home dust endotoxin levels. The primary outcome was maximum asthma symptom-days per 2-week period.
resultsClassrooms had higher settled dust endotoxin levels compared with homes (14.3 endotoxin unit/mg vs 11.3 endotoxin unit/mg; P = .02). Airborne endotoxin levels exceeding recommended occupational exposure limits for adults were recorded in 22.0% of classrooms. Classroom air endotoxin levels were independently associated with increased maximum symptom-days in children with nonatopic asthma, but not in those with atopic asthma (interaction P = .03). Adjusting for home exposures, classroom endotoxin exposure was independently associated with a dose-dependent increase in asthma symptom-days for children with nonatopic asthma (adjusted incidence rate ratio, 1.16 [95% CI, 1.03-1.31]; P = .02). In these subjects, maximum symptom-days increased by 1.3 days for each 14-day period when comparing students in classrooms with the lowest endotoxin levels compared with average measured levels.
conclusionsInner-city children with asthma are exposed to high levels of airborne endotoxin at school, resulting in increased asthma symptoms in children with nonatopic asthma. Mitigation of school-related exposures may represent a strategy to decrease asthma morbidity in this population. TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT01756391; URL: www.clinicaltrials.gov.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.