ArticleGenetics in medicine : official journal of the American College of Medical Genetics2016
Fetal growth and gestational factors as predictors of schizophrenia in 22q11.2 deletion syndrome.
Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Clinically Relevant Genetic Considerations for Patients With Tetralogy of Fallot.CJC pediatric and congenital heart disease · 2023Review
- Review
- Positive cfDNA screening results for 22q11.2 deletion syndrome-Clinical and laboratory considerations.Frontiers in genetics · 2023Article
- Identifying neurodevelopmental anomalies of white matter microstructure associated with high risk for psychosis in 22q11.2DS.Translational psychiatry · 2020Article
- The role of 22q11.2 deletion syndrome in the relationship between congenital heart disease and scoliosis.The spine journal : official journal of the North American Spine Society · 2020Article
- Elucidating the diagnostic odyssey of 22q11.2 deletion syndrome.American journal of medical genetics. Part A · 2018Article
- A Mini Review on the Contribution of the Anterior Cingulate Cortex in the Risk of Psychosis in 22q11.2 Deletion Syndrome.Frontiers in psychiatry · 2018Review
- Obesity in adults with 22q11.2 deletion syndrome.Genetics in medicine : official journal of the American College of Medical Genetics · 2017Article
- Whole-genome sequencing suggests mechanisms for 22q11.2 deletion-associated Parkinson's disease.PloS one · 2017Article
- Neuropsychiatric aspects of 22q11.2 deletion syndrome: considerations in the prenatal setting.Prenatal diagnosis · 2017Article
- Association between prematurity and the evolution of psychotic disorders in 22q11.2 deletion syndrome.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- 22q11.2 deletion syndrome.Nature reviews. Disease primers · 2015Review
- Article
- Immunoreactivity of MAPK Signaling in a Rat Model of Intrauterine Growth Retardation Induced by Uterine Artery Ligation.In vivo (Athens, Greece)Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeSchizophrenia occurs in 20-25% of adults with 22q11.2 deletion syndrome (22q11.2DS). General population studies of schizophrenia report associations with perinatal complications, although effect sizes are generally low. We aimed to determine whether such factors are associated with expression of schizophrenia in individuals with 22q11.2DS.
methodsWe investigated the relationship of small for gestational age (SGA) birth weight (<3rd percentile for sex and gestational age) and prematurity (<37 weeks gestation) to expression of schizophrenia in a well-characterized cohort of 123 adults with 22q11.2DS. Outcome measures included adjusted odds ratios and positive and negative predictive values (PPV and NPV) for schizophrenia.
resultsSGA birth weight (OR = 3.52, 95% CI = 1.34-9.22) and prematurity (OR = 5.38, 95% CI = 1.63-17.75), but not maternal factors, were significant risk factors for schizophrenia in 22q11.2DS. Being born SGA or premature resulted in a PPV of 46% for schizophrenia; NPV in the absence of both features was 83%. Post hoc analyses suggested these perinatal complications were also associated with factors indicative of increased severity of schizophrenia.
conclusionIn 22q11.2DS, fetal growth and gestation may have a clinically significant impact on future risk for schizophrenia. These data advance our understanding of determinants of disease-specific expression in 22q11.2DS, with implications for other genomic disorders.Genet Med 18 4, 350-355.
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