ArticleClinical and translational gastroenterology2015
The Influence of the Gut Microbiome on Obesity, Metabolic Syndrome and Gastrointestinal Disease.
Article in Clinical and translational gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03785418 (Lifestyle Modification for the Treatment of Symptomatic Atrial Fibrillation - A Pilot Study - The LIFE-AF Trial), which is not on this map. Cited by 118 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lifestyle Modification for the Treatment of Symptomatic Atrial Fibrillation - A Pilot Study - The LIFE-AF Trial
Who cites it
118 citing papers in PubMed, 1 synthesis or guideline pooled it, 222 citations in OpenAlex.
- The metabolic syndrome and its components as prognostic factors in colorectal cancer: A meta-analysis and systematic review.Journal of gastroenterology and hepatology · 2023Pooled it
- Effects of Probiotic and Dietary Fiber Supplementation on Metabolic Syndrome-Related Features, Mood, and Sleep in Adults with Obesity.Nutrients · 2026Trial
- Fecal microbial transplantation and fiber supplementation in patients with severe obesity and metabolic syndrome: a randomized double-blind, placebo-controlled phase 2 trial.Nature medicine · 2021Trial
- Molecular Mechanisms of Gut Microbiota-Immune System Crosstalk: From Mucosal Architecture to Adaptive Immunity Programming.International journal of molecular sciences · 2026Review
- Gut Microbiota-Mediated Mechanisms of Traditional Chinese Medicine in Obesity Management.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- The Role of the Microbiome in Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Microbiome composition and co-occurrence dynamics in wildMicrobiology spectrum · 2025Article
- Using Gut Microbiota Modulation as a Precision Strategy Against Obesity.International journal of molecular sciences · 2025Review
- Dysbiosis and colorectal cancer: conducive factors, biological and molecular role, and therapeutic prospectives.Exploration of targeted anti-tumor therapy · 2025Review
- Unveiling roles of beneficial gut bacteria and optimal diets for health.Frontiers in microbiology · 2025Review
- Probiotic, Postbiotic, and Paraprobiotic Effects ofFoods (Basel, Switzerland) · 2024Review
- Multiplatform metabolomic interlaboratory study of a whole human stool candidate reference material from omnivore and vegan donors.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Insights into the ecology of the infant gut plasmidome.Nature communications · 2024Article
- CD71 + erythroid cells promote intestinal symbiotic microbial communities in pregnancy and neonatal period.Microbiome · 2024Article
- Identification of volatile metabolites produced from levodopa metabolism by different bacteria strains of the gut microbiome.BMC microbiology · 2024Article
- Advances in molecular mechanisms of inflammatory bowel disease‑associated colorectal cancer (Review).Oncology letters · 2024Review
- The Association Between Lactational Infective Mastitis and the Microbiome: Development, Onset, and Treatments.Cureus · 2024Review
- Cohort profile of an early life observational cohort in China: Bone and MicroBiOme onset (BAMBOO) study.BMJ open · 2024Observational
- The influence of the gut-brain axis on anxiety and depression: A review of the literature on the use of probiotics.Journal of traditional and complementary medicine · 2024Review
- Update on the gut microbiome in health and diseases.World journal of methodology · 2024Review
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a fine balance in the mutual relationship between the intestinal microbiota and its mammalian host. It is thought that disruptions in this fine balance contribute/account for the pathogenesis of many diseases. Recently, the significance of the relationship between gut microbiota and its mammalian host in the pathogenesis of obesity and the metabolic syndrome has been demonstrated. Emerging data has linked intestinal dysbiosis to several gastrointestinal diseases including inflammatory bowel disease, irritable bowel syndrome, nonalcoholic fatty liver disease, and gastrointestinal malignancy. This article is intended to review the role of gut microbiota maintenance/alterations of gut microbiota as a significant factor as a significant factor discriminating between health and common diseases. Based on current available data, the role of microbial manipulation in disease management remains to be further defined and a focus for further clinical investigation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.