ArticlePloS one2015
Use of the Analysis of the Volatile Faecal Metabolome in Screening for Colorectal Cancer.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Diagnostic performance of volatile organic compounds analysis and electronic noses for detecting colorectal cancer: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Volatile organic compounds as a potential screening tool for neoplasm of the digestive system: a meta-analysis.Scientific reports · 2021Pooled it
- Volatile organic compounds analysis as a potential novel screening tool for colorectal cancer: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Fecal volatile organic compounds for early detection of colorectal cancer: where are we now?Journal of cancer research and clinical oncology · 2019Pooled it
- Colorectal Cancer Detection Through Sweat Volatilome Using an Electronic Nose System and GC-MS Analysis.Cancers · 2025Article
- Faecal Volatile Organic Compounds to Detect Colorectal Neoplasia in Lynch Syndrome-A Prospective Longitudinal Multicentre Study.Alimentary pharmacology & therapeutics · 2025Article
- The human volatilome meets cancer diagnostics: past, present, and future of noninvasive applications.Metabolomics : Official journal of the Metabolomic Society · 2024Review
- Volatile Organic Compound Assessment as a Screening Tool for Early Detection of Gastrointestinal Diseases.Microorganisms · 2023Review
- The Versatility and Diagnostic Potential of VOC Profiling for Noninfectious Diseases.BME frontiers · 2023Article
- Systematic Review: Contribution of the Gut Microbiome to the Volatile Metabolic Fingerprint of Colorectal Neoplasia.Metabolites · 2022Review
- Biomarkers to Detect Early-Stage Colorectal Cancer.Biomedicines · 2022Review
- Novel Diagnostic Biomarkers in Colorectal Cancer.International journal of molecular sciences · 2022Review
- Fecal biomarkers: Non-invasive diagnosis of colorectal cancer.Frontiers in oncology · 2022Review
- Non-Invasive Detection and Staging of Colorectal Cancer Using a Portable Electronic Nose.Sensors (Basel, Switzerland) · 2021Article
- Review
- Volatile organic compounds in breath can serve as a non-invasive diagnostic biomarker for the detection of advanced adenomas and colorectal cancer.Alimentary pharmacology & therapeutics · 2020Article
- Monitoring type 2 diabetes from volatile faecal metabolome in Cushing's syndrome and single Afmid mouse models via a longitudinal study.Scientific reports · 2019Article
- Identification of volatile biomarkers of Giardia duodenalis infection in children with persistent diarrhoea.Parasitology research · 2019Article
- Global Plasma Profiling for Colorectal Cancer-Associated Volatile Organic Compounds: a Proof-of-Principle Study.Journal of chromatographic science · 2019Article
- Colorectal cancer and adenoma screening using urinary volatile organic compound (VOC) detection: early results from a single-centre bowel screening population (UK BCSP).Techniques in coloproctology · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diagnosis of colorectal cancer is an invasive and expensive colonoscopy, which is usually carried out after a positive screening test. Unfortunately, existing screening tests lack specificity and sensitivity, hence many unnecessary colonoscopies are performed. Here we report on a potential new screening test for colorectal cancer based on the analysis of volatile organic compounds (VOCs) in the headspace of faecal samples. Faecal samples were obtained from subjects who had a positive faecal occult blood sample (FOBT). Subjects subsequently had colonoscopies performed to classify them into low risk (non-cancer) and high risk (colorectal cancer) groups. Volatile organic compounds were analysed by selected ion flow tube mass spectrometry (SIFT-MS) and then data were analysed using both univariate and multivariate statistical methods. Ions most likely from hydrogen sulphide, dimethyl sulphide and dimethyl disulphide are statistically significantly higher in samples from high risk rather than low risk subjects. Results using multivariate methods show that the test gives a correct classification of 75% with 78% specificity and 72% sensitivity on FOBT positive samples, offering a potentially effective alternative to FOBT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.