ArticlePloS one2015
Pathology in Captive Wild Felids at German Zoological Gardens.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 77 citations in OpenAlex.
- Assessment of the Thyroid Profile in the Iberian Lynx (Veterinary sciences · 2026Article
- Laparoscopic-assisted ovariohysterectomy for pyometra with concurrent endometriosis in a captive cheetah (Open veterinary journal · 2025Article
- Diagnostic Approach and Pathological Characterization of Metastatic Intrahepatic Cholangiocarcinoma in a Captive Puma (Animals : an open access journal from MDPI · 2025Article
- Enteritis in raccoons (Procyon lotor) caused by an infection with zoonotic Salmonella and carnivore parvovirus.BMC veterinary research · 2025Article
- Case Report: Clinical and pathological features of a metastasizing malignant mixed epithelial and stromal tumor of the kidney in a Siberian tiger (Frontiers in veterinary science · 2025Article
- Gingival squamous cell carcinoma in 2 lions under managed care.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Article
- Clinical presentation, diagnostic investigations and follow-up of a Bengal tiger (Brazilian journal of veterinary medicine · 2024Article
- Chronic kidney disease in a giant panda (Ailuropoda melanoleuca): a case report.BMC veterinary research · 2023Article
- Bridging clinic and wildlife care with AI-powered pan-species computational pathology.Nature communications · 2023Article
- Primary Ovarian Leiomyoma in a White Tiger (Veterinary sciences · 2022Article
- Article
- Leiomyosarcoma with widespread metastases in a capybara.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022Article
- Sinonasal Meningioma in a Siberian Tiger (Veterinary sciences · 2022Article
- Of Elephants and Other Mammals: A Comparative Review of Reproductive Tumors and Potential Impact on Conservation.Animals : an open access journal from MDPI · 2022Review
- Magnetic Resonance Imaging in 50 Captive Non-domestic Felids - Technique and Imaging Diagnoses.Frontiers in veterinary science · 2022Article
- An Overview of Neoplasia in Captive Wild Felids in Southern Italy Zoos.Frontiers in veterinary science · 2022Article
- Manipulating the exposome to enable better ageing.The Biochemical journal · 2021Article
- Immunohistochemical characterization of mesothelioma in 6 large felids.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2021Article
- Case Report: A Case Series Linked to Vitamin D Excess in Pet Food: Cholecalciferol (Vitamin D3) Toxicity Observed in Five Cats.Frontiers in veterinary science · 2021Article
- Biomimetics provides lessons from nature for contemporary ways to improve human health.Journal of clinical and translational science · 2021Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This retrospective study provides an overview on spontaneous diseases occurring in 38 captive wild felids submitted for necropsy by German zoological gardens between 2004 and 2013. Species included 18 tigers, 8 leopards, 7 lions, 3 cheetahs and 2 cougars with an age ranging from 0.5 to 22 years. Renal lesions, predominantly tubular alterations (intra-tubular concrements, tubular degeneration, necrosis, intra-tubular cellular debris, proteinaceous casts, dilated tubuli) followed by interstitial (lympho-plasmacytic inflammation, fibrosis, metastatic-suppurative inflammation, eosinophilic inflammation) and glomerular lesions (glomerulonephritis, glomerulosclerosis, amyloidosis) were detected in 33 out of 38 animals (87%). Tumors were found in 19 of 38 felids (50%) with 12 animals showing more than one neoplasm. The tumor prevalence increased with age. Neoplasms originated from endocrine (11), genital (8), lympho-hematopoietic (5) and alimentary organs (4) as well as the mesothelium (3). Most common neoplasms comprised uterine/ovarian leiomyomas (5/2), thyroid adenomas/adenocarcinoma (5/1), pleural mesotheliomas (3), hemangiosarcomas (2) and glossal papillomas (2). Inflammatory changes were frequently encountered in the intestine and the lung. Two young animals displayed metastatic mineralization suggestive of a vitamin D- or calcium intoxication. One tiger exhibited degenerative white matter changes consistent with an entity termed large felid leukoencephalomyelopathy. Various hyperplastic, degenerative and inflammatory changes with minor clinical significance were found in several organs. Summarized, renal lesions followed by neoplastic changes as well as inflammatory changes in lung and gastrointestinal tract represent the most frequent findings in captive wild felids living in German zoological gardens.
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Registered trials
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