ArticleScientific reports2015
Bacterial growth and form under mechanical compression.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- A lab-on-a-silicon-chip platform for all-electrical antibiotic susceptibility tests with a sample-to-results time within 20 minutes.Science advances · 2026Article
- A microfluidic rheometer for tumor mechanics and invasion studies.Lab on a chip · 2025Article
- Bacterial cell widening alters periplasmic size and activates envelope stress responses.The EMBO journal · 2025Article
- A microfluidic rheometer for tumor mechanics and invasion studies.bioRxiv : the preprint server for biology · 2025Article
- Mechanics ofMolecular biology of the cell · 2025Article
- Colony pattern multistability emerges from a bistable switch.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Growth of nonmotile stress-responsive bacteria in 3D colonies under confining pressure.Biophysical journal · 2025Article
- Hyper-porous encapsulation of microbes for whole cell biocatalysis and biomanufacturing.Microbial cell factories · 2025Article
- Decoding physical principles of cell migration under controlled environment using microfluidics.Biophysics reviews · 2024Review
- A Novel Fractional Brownian Dynamics Method for Simulating the Dynamics of Confined Bottle-Brush Polymers in Viscoelastic Solution.Polymers · 2024Article
- Energy allocation theory for bacterial growth control in and out of steady state.bioRxiv : the preprint server for biology · 2024Article
- Article
- Mechanical compression creates a quiescent muscle stem cell niche.Communications biology · 2023Article
- The Power of Touch: Type 4 Pili, the von Willebrand A Domain, and Surface Sensing by Pseudomonas aeruginosa.Journal of bacteriology · 2022Review
- Biochip with multi-planar electrodes geometry for differentiation of non-spherical bioparticles in a microchannel.Scientific reports · 2021Article
- Mesoscale Simulation of Bacterial Chromosome and Cytoplasmic Nanoparticles in Confinement.Entropy (Basel, Switzerland) · 2021Article
- Are bacteria claustrophobic? The problem of micrometric spatial confinement for the culturing of micro-organisms.RSC advances · 2021Article
- Artificial modulation of cell width significantly affects the division time of Escherichia coli.Scientific reports · 2020Article
- Correlative ex situ and Liquid-Cell TEM Observation of Bacterial Cell Membrane Damage Induced by Rough Surface Topology.International journal of nanomedicine · 2020Article
- Moran Model of Spatial Alignment in Microbial Colonies.Physica D. Nonlinear phenomena · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A combination of physical and chemical processes is involved in determining the bacterial cell shape. In standard medium, Escherichia coli cells are rod-shaped, and maintain a constant diameter during exponential growth. Here, we demonstrate that by applying compressive forces to growing E. coli, cells no longer retain their rod-like shapes but grow and divide with a flat pancake-like geometry. The deformation is reversible: deformed cells can recover back to rod-like shapes in several generations after compressive forces are removed. During compression, the cell elongation rate, proliferation rate, DNA replication rate, and protein synthesis are not significantly altered from those of the normal rod-shaped cells. Quantifying the rate of cell wall growth under compression reveals that the cell wall growth rate depends on the local cell curvature. MreB not only influences the rate of cell wall growth, but also influences how the growth rate scales with cell geometry. The result is consistent with predictions of a mechanochemical model, and suggests an active mechanical role for MreB during cell wall growth. The developed compressive device is also useful for studying a variety of cells in unique geometries.
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