Evidence map›Paper›PMID 26086366›Full record

ArticleBrain research2015

Paclitaxel improves outcome from traumatic brain injury.

Donna J Cross, Gregory G Garwin, Marcella M Cline, Todd L Richards, Vasily Yarnykh, Pierre D Mourad, Rodney J Y Ho, Satoshi Minoshima

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Microtubule-Stabilizing 1,2,4-Triazolo[1,5-Journal of medicinal chemistry · 2023
    Article
  4. Article
  5. Article
  6. Review
  7. Paclitaxel Reduces Brain Injury from Repeated Head Trauma in Mice.Journal of Alzheimer's disease : JAD · 2019
    Article
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Donna J CrossDepartment of Radiology, University of Washington, 1959 N.E. Pacific Street, Seattle, WA, 98195-7115, USA. Electronic address: dcross@uw.edu.
Gregory G GarwinDepartment of Radiology, University of Washington, 1959 N.E. Pacific Street, Seattle, WA, 98195-7115, USA.
Marcella M ClineDepartment of Radiology, University of Washington, 1959 N.E. Pacific Street, Seattle, WA, 98195-7115, USA.
Todd L RichardsDepartment of Radiology, University of Washington, 1959 N.E. Pacific Street, Seattle, WA, 98195-7115, USA.
Vasily YarnykhDepartment of Radiology, University of Washington, 1959 N.E. Pacific Street, Seattle, WA, 98195-7115, USA.
Pierre D MouradDepartment of Neurological Surgery, University of Washington, 1959 N.E. Pacific Street, Seattle, WA 98195-7115, USA.
Rodney J Y HoDepartment of Pharmaceutics, University of Washington, 1959 N.E. Pacific Street, Seattle, WA 98195-7115, USA.
Satoshi MinoshimaDepartment of Radiology, University of Utah, 30 North 1900 East, Salt Lake City, UT 84132, USA.
University of Washington · USUniversity of Utah · US

Funding

YILMA SIV VACCINIA VACCINE TRIALP51RR000166 · NCRR · UNIVERSITY OF WASHINGTON · PI HU, SHIU-LOK · 1985 to 2011
$161.1M
Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
Targeted Long-acting Combination Antiretroviral Therapy (TLC-ART)UM1AI120176 · NIAID · UNIVERSITY OF WASHINGTON · PI COLLIER, ANN CORNWALL, HO, RODNEY J.Y. · 2015 to 2019
$15.0M
NCATS NIH HHS UL1 TR000423NCATS NIH HHS UL1TR000423NIAID NIH HHS UM1 AI120176
6 · The paper itself

Abstract

Pharmacologic interventions for traumatic brain injury (TBI) hold promise to improve outcome. The purpose of this study was to determine if the microtubule stabilizing therapeutic paclitaxel used for more than 20 years in chemotherapy would improve outcome after TBI. We assessed neurological outcome in mice that received direct application of paclitaxel to brain injury from controlled cortical impact (CCI). Magnetic resonance imaging was used to assess injury-related morphological changes. Catwalk Gait analysis showed significant improvement in the paclitaxel group on a variety of parameters compared to the saline group. MRI analysis revealed that paclitaxel treatment resulted in significantly reduced edema volume at site-of-injury (11.92 ± 3.0 and 8.86 ± 2.2mm(3) for saline vs. paclitaxel respectively, as determined by T2-weighted analysis; p ≤ 0.05), and significantly increased myelin tissue preservation (9.45 ± 0.4 vs. 8.95 ± 0.3, p ≤ 0.05). Our findings indicate that paclitaxel treatment resulted in improvement of neurological outcome and MR imaging biomarkers of injury. These results could have a significant impact on therapeutic developments to treat traumatic brain injury.

Indexed as

Treatment OutcomeAnimalsBrain InjuriesDisease Models, AnimalGait Disorders, NeurologicMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLPaclitaxelTubulin ModulatorsPaclitaxelTubulin ModulatorsMicrotubule stabilizationMR imagingNeurological functionTraumatic brain injury

Identifiers

PMID26086366
PMCPMC4767255
OpenAlexW560582331

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.