Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2016
Sleep duration, cognitive decline, and dementia risk in older women.
Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
130 citing papers in PubMed, 8 syntheses or guidelines pooled it, 235 citations in OpenAlex.
- Sleep and cognition in Hispanic/Latin American adults: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
- Pooled it
- Sleep disorders and the risk of cognitive decline or dementia: an updated systematic review and meta-analysis of longitudinal studies.Journal of neurology · 2025Pooled it
- Effect of Excessive Daytime Sleepiness and Long Sleep Duration on All Cause Dementia: A Systematic Review and Meta-analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Pooled it
- Sleep duration and health outcomes: an umbrella review.Sleep & breathing = Schlaf & Atmung · 2022Pooled it
- Pooled it
- Benzodiazepines and Related Drugs as a Risk Factor in Alzheimer's Disease Dementia.Frontiers in aging neuroscience · 2019Pooled it
- A systematic review and dose-response meta-analysis of sleep duration and the occurrence of cognitive disorders.Sleep & breathing = Schlaf & Atmung · 2018Pooled it
- Effects of Meditation and Music-Listening on Blood Biomarkers of Cellular Aging and Alzheimer's Disease in Adults with Subjective Cognitive Decline: An Exploratory Randomized Clinical Trial.Journal of Alzheimer's disease : JAD · 2018Trial
- Article
- Article
- The combined association between sleep duration and insomnia symptoms with dementia and cognitive deficits: a multivariable-adjusted and genetic liability study.GeroScience · 2026Article
- The interaction of sleep characteristics and work-related stress in relation to the risk of dementia: findings from a Swedish cohort study.European journal of epidemiology · 2026Article
- Glial cytokine modulation improves sleep and circadian disruption in female SAA knock-in mice of Alzheimer's-related pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Comparative analysis of multimorbidity prevalence and lifestyle factors among older adults in frigid versus non-frigid zones of China.BMC public health · 2026Article
- Physical Activity and Cognitive Function in Postmenpausal Women: Depressive Symptoms and Sleep Disorder as Sequential Mediators.Psychology research and behavior management · 2026Article
- Association between sleep duration and depressive symptoms among older adults in China: a national cross-sectional study.Frontiers in psychiatry · 2026Article
- Sleep electroencephalography-derived brain health and long-term cognitive decline in community-dwelling adults.Sleep advances : a journal of the Sleep Research Society · 2026Article
- The Effect of Sleep Deprivation on Cognitive Function in Postmenopausal Women: A Systematic Review.International journal of women's health · 2026Review
- Urban-rural differences and bidirectional association between social participation and cognitive function among Chinese older adults: a 10-year prospective cohort study.Archives of public health = Archives belges de sante publique · 2025Article
70 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 11 institutions in 1 country.
Funding
Abstract
introductionConsistent evidence linking habitual sleep duration with risks of mild cognitive impairment (MCI) and dementia is lacking.
methodsWe conducted a prospective study on 7444 community-dwelling women (aged 65-80 y) with self-reported sleep duration, within the Women's Health Initiative Memory Study in 1995-2008. Incident MCI/dementia cases were ascertained by validated protocols. Cox models were used to adjust for multiple sociodemographic and lifestyle factors, depression, cardiovascular disease (CVD), and other clinical characteristics.
resultsWe found a statistically significant (P = .03) V-shaped association with a higher MCI/dementia risk in women with either short (≤6 hours/night) or long (≥8 hours/night) sleep duration (vs. 7 hours/night). The multicovariate-adjusted hazard for MCI/dementia was increased by 36% in short sleepers irrespective of CVD, and by 35% in long sleepers without CVD. A similar V-shaped association was found with cognitive decline. DISCUSSION: In older women, habitual sleep duration predicts the future risk for cognitive impairments including dementia, independent of vascular risk factors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.