ArticleThe Analyst2015
Biophysical separation of Staphylococcus epidermidis strains based on antibiotic resistance.
Article in The Analyst, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Quantifying and Minimizing the Variance of Gradient Insulator-Based Dielectrophoresis.Micromachines · 2026Article
- Article
- High-Throughput Continuous Free-Flow Dielectrophoretic Trapping of Micron-Scale Particles and Cells in Paper Using Localized Nonuniform Pore-Scale-Generated Paper-Based Electric Field Gradients.Analytical chemistry · 2024Article
- A numerical study on microfluidic devices to maintain the concentration and purity of dielectrophoresis-induced separated fractions of analyte.Analytical and bioanalytical chemistry · 2023Article
- Electromagnetic Forces and Torques: From Dielectrophoresis to Optical Tweezers.Chemical reviews · 2023Review
- Leveraging microfluidic dielectrophoresis to distinguish compositional variations of lipopolysaccharide inFrontiers in bioengineering and biotechnology · 2023Article
- Fine-Tuning Electrokinetic Injections Considering Nonlinear Electrokinetic Effects in Insulator-Based Devices.Micromachines · 2021Article
- Determination of the Empirical Electrokinetic Equilibrium Condition of Microorganisms in Microfluidic Devices.Biosensors · 2020Article
- Study on non-bioparticles andRSC advances · 2020Article
- Differential Biophysical Behaviors of Closely Related Strains of Salmonella.Frontiers in microbiology · 2020Article
- Effects of surface treatments on trapping with DC insulator-based dielectrophoresis.The Analyst · 2019Article
- Isolation and identification of Listeria monocytogenes utilizing DC insulator-based dielectrophoresis.Analytica chimica acta · 2019Article
- Identification of neural stem and progenitor cell subpopulations using DC insulator-based dielectrophoresis.The Analyst · 2019Article
- A mathematical model of dielectrophoretic data to connect measurements with cell properties.Analytical and bioanalytical chemistry · 2019Article
- Microfluidic dielectrophoresis illuminates the relationship between microbial cell envelope polarizability and electrochemical activity.Science advances · 2019Article
- Single-cell electro-phenotyping for rapid assessment ofSensors and actuators. B, Chemical · 2018Article
- Analysis of the dielectrophoretic properties of cells using the isomotive AC electric field.Biomicrofluidics · 2018Article
- Review: Microbial analysis in dielectrophoretic microfluidic systems.Analytica chimica acta · 2017Review
- Refinement of insulator-based dielectrophoresis.The Analyst · 2017Article
- CORR Insights(®): The Alpha-defensin Test for Periprosthetic Joint Infection is Not Affected by Prior Antibiotic Administration.Clinical orthopaedics and related research · 2016Article
Corrections and comments
- Erratum issuedCorrection: Biophysical separation of Staphylococcus epidermidis strains based on antibiotic resistance.2016 · Yanashima, Ryan [added]
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrophoretic and dielectrophoretic approaches to separations can provide unique capabilities. In the past, capillary and microchip-based approaches to electrophoresis have demonstrated extremely high-resolution separations. More recently, dielectrophoretic systems have shown excellent results for the separation of bioparticles. Here we demonstrate resolution of a difficult pair of targets: gentamicin resistant and susceptible strains of Staphylococcus epidermidis. This separation has significant potential implications for healthcare. This establishes a foundation for biophysical separations as a direct diagnostic tool, potentially improving nearly every figure of merit for diagnostics and antibiotic stewardship. The separations are performed on a modified gradient insulator-based dielectrophoresis (g-iDEP) system and demonstrate that the presence of antibiotic resistance enzymes (or secondary effects) produces a sufficient degree of electrophysical difference to allow separation. The differentiating factor is the ratio of electrophoretic to dielectrophoretic mobilities. This factor is 4.6 ± 0.6 × 10(9) V m(-2) for the resistant strain, versus 9.2 ± 0.4 × 10(9) V m(-2) for the susceptible strain. Using g-iDEP separation, this difference produces clear and easily discerned differentiation of the two strains.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.