ArticleInternational journal of ophthalmology2015
Treatment of ocular rosacea: comparative study of topical cyclosporine and oral doxycycline.
Article in International journal of ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- [Rosacea-the updated S2k guideline].Dermatologie (Heidelberg, Germany) · 2023Guideline
- Preferred practice patterns and review on rosacea.Indian journal of ophthalmology · 2023Guideline
- Topical cyclosporine A therapy for dry eye syndrome.The Cochrane database of systematic reviews · 2019Pooled it
- Interventions for rosacea based on the phenotype approach: an updated systematic review including GRADE assessments.The British journal of dermatology · 2019Pooled it
- The Latest Advances in Rosacea Treatment: A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Pharmacological, Natural and Emerging Therapies for Meibomian Gland Dysfunction: A Review.Drugs · 2026Review
- Recurrent Red Eye Misdiagnosed as Conjunctivitis: Ocular Rosacea With Corneal Neovascularization in a Young Patient.Cureus · 2026Article
- [Ocular rosacea : Clinical aspects, diagnostics, management and treatment].Dermatologie (Heidelberg, Germany) · 2026Review
- [Ocular rosacea : Clinical aspects, diagnostics, management and treatment].Die Ophthalmologie · 2025Review
- Ocular Rosacea: An Updated Review.Cornea · 2025Review
- Corticosteroid-sparing topical treatment with cyclosporin for juvenile keratoconjunctivitis.Scientific reports · 2025Article
- Rosacea in Older Adults and Pharmacologic Treatments.Drugs & aging · 2024Review
- A Review of the Diagnostic and Therapeutic Gaps in Rosacea Management: Consensus Opinion.Dermatology and therapy · 2024Article
- Rosacea: Practical Guidance and Challenges for Clinical Management.Clinical, cosmetic and investigational dermatology · 2024Review
- Relationship between ocular surface temperature and 0.1% cyclosporine a in dry eye syndrome with meibomian gland dysfunction.PloS one · 2023Article
- Common ocular findings in patients with acne rosacea.International ophthalmology · 2022Article
- Association Between Skin Findings and Ocular Signs in Rosacea.Turkish journal of ophthalmology · 2021Article
- Clinical manifestations and long-term outcomes in three ocular rosacea cases treated at a highly specialized hospital in southeast MéxicoBiomedica : revista del Instituto Nacional de Salud · 2020Article
- Review
- Dry Eye Disease: Consideration for Women's Health.Journal of women's health (2002) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo compare the effectiveness of topical cyclosporine A emulsion with that of oral doxycycline for rosacea associated ocular changes and dry eye complaints.
methodsOne hundred and ten patients with rosacea were screened. Thirty-eight patients having rosacea associated eyelid and ocular surface changes and dry eye complaints were included in the study. Patients were randomly divided into two groups: nineteen patients were given topical cyclosporine twice daily and nineteen patients were given oral doxycycline 100 mg twice daily for the first month and once daily for the following two months. Symptom and sign scores, ocular surface disease index questionnarie and tear function tests were evaluated at baseline and monthly for 3mo. Three months after results were compared with that of baseline.
resultsMean values of symptom, eyelid sign and corneal/conjunctival sign scores of each treatment group at baseline and 3mo after treatments were compared and both drugs were found to be effective on rosacea associated ocular changes (P<0.001). Cyclosporine was more effective in symptomatic relief and in the treatment of eyelid signs (P=0.01). There was statistically significant increase in the mean Schirmer score with anesthesia and tear break up time scores in the cyclosporine treatment group compared to the doxycycline treatment group (P<0.05).
conclusionCyclosporine as a topical drug can be used in the treatment of rosacea associated ocular complications because it is more effective than doxycycline. In addition ocular rosacea as a chronic disease requires long term treatment and doxycycline has various side effects limiting its long term usage.
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Registered trials
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