Evidence map›Paper›PMID 26085962›Full record

ArticleBrain and behavior2015

A P300-based cognitive assessment battery.

Aaron Kirschner, Damian Cruse, Srivas Chennu, Adrian M Owen, Adam Hampshire

Abstract read
In one paragraph

Article in Brain and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aaron KirschnerThe Brain and Mind Institute, University of Western Ontario London, Ontario, Canada.
Damian CruseThe Brain and Mind Institute, University of Western Ontario London, Ontario, Canada.
Srivas ChennuDepartment of Clinical Neurosciences, The University of Cambridge Cambridge, UK.
Adrian M OwenThe Brain and Mind Institute, University of Western Ontario London, Ontario, Canada.
Adam HampshireThe Computational, Cognitive and Clinical Neuroimaging Laboratory, Division of Brain Sciences, Imperial College London London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is well established that some patients who are diagnosed as being in a vegetative state or a minimally conscious state show reliable signs of volition that may only be detected by measuring neural responses. A pertinent question is whether these patients are capable of higher cognitive processes.

methodsHere, we develop a series of EEG paradigms that probe several core aspects of cognition at the bedside without the need for motor responses and explore the sensitivity of this approach in a group of healthy controls.

resultsUsing analysis of ERPs alone, this method can determine with high reliability whether individual participants are able to attend a stimulus stream, maintain items in working memory, or solve complex grammatical reasoning problems.

conclusionWe suggest that this approach could form the basis of a brain-based battery for assessing higher cognition in patients with severe motor impairments or disorders of consciousness.

Indexed as

Persistent Vegetative StateCognitionElectroencephalographyEvoked PotentialsFemaleHealthy VolunteersHumansMaleMemory, Short-TermPoint-of-Care TestingReproducibility of ResultsSensitivity and SpecificitySynaptic TransmissionTask Performance and AnalysisYoung AdultAttentioncognitive assessmentEEGP300reasoningworking memory

Identifiers

PMID26085962
PMCPMC4467771

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.