SynthesisBrain and behavior2015
Patterns of gray matter atrophy in atypical parkinsonism syndromes: a VBM meta-analysis.
Synthesis in Brain and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 7 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases.Frontiers in neuroscience · 2021Pooled it
- Voxel-Based Meta-Analysis of Gray Matter Abnormalities in Multiple System Atrophy.Frontiers in aging neuroscience · 2020Pooled it
- Localised grey matter atrophy in multiple sclerosis is network-based: a coordinate-based meta-analysis.Clinical radiology · 2019Pooled it
- Atrophy in midbrain & cerebral/cerebellar pedunculi is characteristic for progressive supranuclear palsy - A double-validation whole-brain meta-analysis.NeuroImage. Clinical · 2019Pooled it
- FDG-PET hypometabolism is more sensitive than MRI atrophy in Parkinson's disease: A whole-brain multimodal imaging meta-analysis.NeuroImage. Clinical · 2019Pooled it
- Characterisation of meta-analytical functional connectivity in progressive supranuclear palsy.Clinical radiology · 2018Pooled it
- Diffusion tensor imaging in Parkinson's disease: Review and meta-analysis.NeuroImage. Clinical · 2017Pooled it
- Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy.Annals of clinical and translational neurology · 2026Observational
- Brainstem and cerebellar radiological findings in progressive supranuclear palsy.Brain communications · 2025Review
- Large-scale activation likelihood estimation meta-analysis of parkinsonian disorders.Brain communications · 2023Article
- Clinical Spectrum of Tauopathies.Frontiers in neurology · 2022Review
- Temporal Progression Patterns of Brain Atrophy in Corticobasal Syndrome and Progressive Supranuclear Palsy Revealed by Subtype and Stage Inference (SuStaIn).Frontiers in neurology · 2022Article
- Characterizing resting-state networks in Parkinson's disease: A multi-aspect functional connectivity study.Brain and behavior · 2021Article
- Dentatorubrothalamic tract reduction using fixel-based analysis in corticobasal syndrome.Neuroradiology · 2021Article
- Can Autonomic Testing and Imaging Contribute to the Early Diagnosis of Multiple System Atrophy? A Systematic Review and Recommendations by the Movement Disorder Society Multiple System Atrophy Study Group.Movement disorders clinical practice · 2020Review
- Neuroimaging Advances in Parkinson's Disease and Atypical Parkinsonian Syndromes.Frontiers in neurology · 2020Review
- The Role of Magnetic Resonance Imaging for the Diagnosis of Atypical Parkinsonism.Frontiers in neurology · 2020Review
- Article
- Localizing parkinsonism based on focal brain lesions.Brain : a journal of neurology · 2018Article
- Diagnosis of multiple system atrophy.Autonomic neuroscience : basic & clinical · 2018Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeAccurate diagnosis of Atypical Parkinsonian Syndromes (APS) is important due to differences in prognosis and management, but remains a challenge in the clinical setting. The purpose of our meta-analysis was to identify characteristic patterns of gray matter atrophy in Corticobasal Degeneration (CBD), Progressive Supranuclear Palsy (PSP), Multisystem-Atrophy Parkinsonian type (MSA-P), and Idiopathic Parkinson's Disease (IPD). MATERIALS AND
methodsWhole-brain meta-analysis was performed on 39 published voxel-based morphometry (VBM) articles (consisting of 404 IPD, 87 MSA-P, 165 CBD, and 176 PSP subjects) using the modified Anatomic Likelihood Estimation method. Based on these results, contrast analyses were then utilized to determine areas of atrophy shared by as well as unique to each disorder.
resultsCBD was characterized by asymmetric gray matter atrophy in multiple cortical regions, while the thalamus-midbrain and insula were predominantly involved in PSP. The striatum and superior cerebellum were affected in MSA-P, while IPD demonstrated an anterior cerebral pattern. Although there was a mild overlap among PSP, CBD, and MSA-P, significant regions of atrophy unique to each disorder were identified, including (1) the superior parietal lobule in CBD (2) putamen in MSA-P (3) insula and medial dorsal nucleus in PSP.
conclusionOur results suggest that there are characteristic patterns of atrophy in APS. Guided by these findings, future studies on the individual subject level may lead to the development of robust imaging biomarkers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.