Evidence map›Paper›PMID 26085947›Full record

ArticleActa naturae

Specific Depletion of Myelin-Reactive B Cells via BCR-Targeting.

A V Stepanov, A A Belogurov, P Kothapalli, O G Shamborant, V D Knorre, G B Telegin, A A Ovsepyan, N A Ponomarenko, S M Deyev, S V Kaveri and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC
In one paragraph

Article in Acta naturae. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Factor VIII-Fc Activates Natural Killer CellsFrontiers in immunology · 2021
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 4 countries.

A V StepanovM.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya Str., 16/10, Russian Academy of Sciences, 117997, Moscow, Russia ; Kazan Federal University, Kremlevskaya Str., 18, 420008, Kazan, Republic of Tatarstan, Russia.
A A BelogurovM.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya Str., 16/10, Russian Academy of Sciences, 117997, Moscow, Russia ; Kazan Federal University, Kremlevskaya Str., 18, 420008, Kazan, Republic of Tatarstan, Russia ; Institute of Gene Biology, Russian Academy of Sciences, Vavilova Str., 34/5, 119334, Moscow, Russia.
P KothapalliCentre de Recherche des Cordeliers, Université Pierre et Marie Curie, UMR S 1138, F-75006, Paris, France.
O G ShamborantM.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya Str., 16/10, Russian Academy of Sciences, 117997, Moscow, Russia.
V D KnorreM.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya Str., 16/10, Russian Academy of Sciences, 117997, Moscow, Russia.
G B TeleginM.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya Str., 16/10, Russian Academy of Sciences, 117997, Moscow, Russia.
A A OvsepyanM.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya Str., 16/10, Russian Academy of Sciences, 117997, Moscow, Russia.
N A PonomarenkoM.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya Str., 16/10, Russian Academy of Sciences, 117997, Moscow, Russia.
S M DeyevM.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya Str., 16/10, Russian Academy of Sciences, 117997, Moscow, Russia.
S V KaveriCentre de Recherche des Cordeliers, Université Pierre et Marie Curie, UMR S 1138, F-75006, Paris, France.
A G GabibovM.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya Str., 16/10, Russian Academy of Sciences, 117997, Moscow, Russia ; Kazan Federal University, Kremlevskaya Str., 18, 420008, Kazan, Republic of Tatarstan, Russia ; Institute of Gene Biology, Russian Academy of Sciences, Vavilova Str., 34/5, 119334, Moscow, Russia.
Institute of Bioorganic Chemistry · BYMarie Curie · GBInstitute of Gene Biology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

B cells play a crucial role in the development and pathogenesis of systemic and organ-specific autoimmune diseases. Autoreactive B cells not only produce antibodies, but also secrete pro-inflammatory cytokines and present specific autoantigens to T cells. The treatment of autoimmune diseases via the elimination of the majority of B cells using the monoclonal anti-CD19/20 antibody (Rituximab) causes systemic side effects and, thus, requires a major revision. Therapeutic intervention directed towards selective elimination of pathogenic autoreactive B cells has the potential to become a universal approach to the treatment of various autoimmune abnormalities. Here, we developed a recombinant immunotoxin based on the immunodominant peptide of the myelin basic protein (MBP), fused to the antibody Fc domain. We showed that the obtained immunotoxin provides selective in vivo elimination of autoreactive B cells in mice with experimental autoimmune encephalomyelitis. The proposed conception may be further used for the development of new therapeutics for a targeted treatment of multiple sclerosis and other autoimmune disorders.

Indexed as

autoantigensB cellsimmunoglobulinsimmunotoxinsmultiple sclerosis

Identifiers

PMID26085947
PMCPMC4463415
OpenAlexW2959056732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.