ArticleActa naturae
Pseudomonas Aeruginosa Lectins As Targets for Novel Antibacterials.
Article in Acta naturae. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 57 citations in OpenAlex.
- Disaccharide-Presenting Iron(II) Complexes as Synthetic Mimics of Natural Glycan Epitopes for Lectin Recognition.Inorganic chemistry · 2026Article
- Mechanisms ofMedicina (Kaunas, Lithuania) · 2026Review
- Effect of supplementation on biofilms and antibiotic efficacy againstIranian journal of microbiology · 2025Review
- A Reversible and Dynamic Surface Functionalization for Fluidity Controlled Multivalent Recognition of Lectins and Bacteria.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Insights onMicroorganisms · 2024Article
- Review
- Tobramycin-loaded complexes to prevent and disrupt Pseudomonas aeruginosa biofilms.Drug delivery and translational research · 2022Article
- Structural Considerations for Building Synthetic Glycoconjugates as Inhibitors for Pseudomonas aeruginosa Lectins.ChemMedChem · 2022Review
- Quorum Sensing Inhibitors to QuenchPharmaceuticals (Basel, Switzerland) · 2021Review
- Malonate utilization by Pseudomonas aeruginosa affects quorum-sensing and virulence and leads to formation of mineralized biofilm-like structures.Molecular microbiology · 2021Article
- Ruthenium-centred btp glycoclusters as inhibitors forRSC advances · 2021Article
- Advances in Understanding of the Copper Homeostasis inInternational journal of molecular sciences · 2021Review
- Article
- The B Subunit of PirABPathogens (Basel, Switzerland) · 2020Article
- The Pseudomonas aeruginosa lectin LecB binds to the exopolysaccharide Psl and stabilizes the biofilm matrix.Nature communications · 2019Article
- Functional Glyco-Nanogels for Multivalent Interaction with Lectins.Molecules (Basel, Switzerland) · 2019Article
- Inhibition ofPathogens (Basel, Switzerland) · 2019Article
- Host Peptidic Hormones Affecting Bacterial Biofilm Formation and Virulence.Journal of innate immunity · 2019Review
- Recent perspectives on the molecular basis of biofilm formation by Pseudomonas aeruginosa and approaches for treatment and biofilm dispersal.Folia microbiologica · 2018Review
- Hetero-Multivalency of Pseudomonas aeruginosa Lectin LecA Binding to Model Membranes.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pseudomonas aeruginosa is one of the most widespread and troublesome opportunistic pathogens that is capable of colonizing various human tissues and organs and is often resistant to many currently used antibiotics. This resistance is caused by different factors, including the acquisition of specific resistance genes, intrinsic capability to diminish antibiotic penetration into the bacterial cell, and the ability to form biofilms. This situation has prompted the development of novel compounds differing in their mechanism of action from traditional antibiotics that suppress the growth of microorganisms or directly kill bacteria. Instead, these new compounds should decrease the pathogens' ability to colonize and damage human tissues by inhibiting the virulence factors and biofilm formation. The lectins LecA and LecB that bind galactose and fucose, as well as oligo- and polysaccharides containing these sugars, are among the most thoroughly-studied targets for such novel antibacterials. In this review, we summarize the results of experiments highlighting the importance of these proteins for P. aeruginosa pathogenicity and provide information on existing lectins inhibitors and their effectiveness in various experimental models. Particular attention is paid to the effects of lectins inhibition in animal models of infection and in clinical practice. We argue that lectins inhibition is a perspective approach to combating P. aeruginosa. However, despite the existence of highly effective in vitro inhibitors, further experiments are required in order to advance these inhibitors into pre-clinical studies.
Indexed as
Identifiers
26085942PMC4463410W1901302611What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.