Evidence map›Paper›PMID 26085823›Full record

ArticleBiological theory2015

A Philosophical Perspective on Evolutionary Systems Biology.

Maureen A O'Malley, Orkun S Soyer, Mark L Siegal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological theory, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. COVID-19: Rethinking the nature of viruses.History and philosophy of the life sciences · 2021
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maureen A O'MalleyDepartment of Philosophy, University of Sydney, Sydney, Australia.
Orkun S SoyerSchool of Life Sciences, University of Warwick, Coventry, UK.
Mark L SiegalDepartment of Biology, Center for Genomics and Systems, Biology, New York University, New York, NY, USA.

Funding

Sequencing yeast lines to measure rates of neutral and deleterious mutationsR01GM097415 · NIGMS · NEW YORK UNIVERSITY · PI PETROV, DMITRI, SIEGAL, MARK L · 2011 to 2014
$2.3M
Sources and consequences of phenotypic variation in complex regulatory networksR01GM086673 · NIGMS · NEW YORK UNIVERSITY · PI SIEGAL, MARK L · 2010 to 2013
$929k
NIGMS NIH HHS R01 GM086673NIGMS NIH HHS R01 GM097415
6 · The paper itself

Abstract

Evolutionary systems biology (ESB) is an emerging hybrid approach that integrates methods, models, and data from evolutionary and systems biology. Drawing on themes that arose at a cross-disciplinary meeting on ESB in 2013, we discuss in detail some of the explanatory friction that arises in the interaction between evolutionary and systems biology. These tensions appear because of different modeling approaches, diverse explanatory aims and strategies, and divergent views about the scope of the evolutionary synthesis. We locate these discussions in the context of long-running philosophical deliberations on explanation, modeling, and theoretical synthesis. We show how many of the issues central to ESB's progress can be understood as general philosophical problems. The benefits of addressing these philosophical issues feed back into philosophy too, because ESB provides excellent examples of scientific practice for the development of philosophy of science and philosophy of biology.

Indexed as

Evolutionary biologyEvolutionary systems biologyExplanationPhilosophy of biologyPhilosophy of scienceSystems biology

Identifiers

PMID26085823
PMCPMC4465572

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.