Evidence map›Paper›PMID 26085696›Full record

ArticleTetrahedron letters2015

Enantioselective Nazarov Cyclization Catalyzed by a Cinchona Alkaloid Derivative.

Yu-Wen Huang, Alison J Frontier

Abstract read
In one paragraph

Article in Tetrahedron letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yu-Wen HuangDepartment of Chemistry, University of Rochester, Rochester, New York 14627, United States.
Alison J FrontierDepartment of Chemistry, University of Rochester, Rochester, New York 14627, United States.

Funding

Asymmetric Synthesis of Bioactive Natural Products Using Nazarov CyclizationR01GM079364 · NIGMS · UNIVERSITY OF ROCHESTER · PI FRONTIER, ALISON J · 2007 to 2013
$2.0M
NIGMS NIH HHS R01 GM079364
6 · The paper itself

Abstract

Nucleophilic catalysts for a 1,6 addition/Nazarov cyclization/elimination sequence were evaluated for their ability to induce enantioselectivity in the electrocyclization step. Of the tertiary amines examined, it was found that a cinchona alkaloid derivative was able to generate substituted 5-hydroxy γ-methylene cyclopentenones with excellent enantioselectivity. The study results suggest that successful cyclization depends upon the ability of the dienyl diketone substrate to readily adopt an

Indexed as

cinchona alkaloidenantioselectiveNazarov cyclization

Identifiers

PMID26085696
PMCPMC4465120

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.