Evidence map›Paper›PMID 26085659›Full record

ReviewThe Journal of experimental biology2015

The emerging role of RNA editing in plasticity.

Joshua J C Rosenthal

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of experimental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 80 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
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  14. Review
  15. Review
  16. Characterization and complexity of transcriptome in Gymnocypris przewalskii using single-molecule long-read sequencing and RNA-seq.DNA research : an international journal for rapid publication of reports on genes and genomes · 2021
    Article
  17. Article
  18. Review
  19. Article
  20. Quantitative Analysis of Adenosine-to-Inosine RNA Editing.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Joshua J C RosenthalUniversidad de Puerto Rico, Recinto de Ciencias Medicas, Instituto de Neurobiologia, 201 Blvd. del Valle, San Juan, PR 00901, USA rosenthal.joshua@gmail.com.
University of Puerto Rico System · PR

Funding

SUPPLEMENT FOR RENOVATION OF ANIMAL FACILITIES AT INSTITUTE OF NEUROBIOLOGYG12RR003051 · NCRR · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI FERNANDEZ-REPOLLET, EMMA · 1986 to 2011
$28.1M
TRANSLATIONAL PROTEOMICS CENTERG12MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI FERNANDEZ-REPOLLET, EMMA · 2012 to 2016
$11.0M
Site-directed RNA editing: a new method to correct disease causing mutationsR01NS087726 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ADELMAN, JOHN P, BREHM, PAUL · 2013 to 2017
$3.4M
Regulation of the Na/K Pump by RNA EditingR01NS064259 · NINDS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI ROSENTHAL, JOSHUA J.C. · 2010 to 2014
$1.5M
NCRR NIH HHS 2G12RR003051NCRR NIH HHS G12 RR003051NIMHD NIH HHS 8G12MD007600NIMHD NIH HHS G12 MD007600NINDS NIH HHS 1R01NS087726-01NINDS NIH HHS 1R01NS64259NINDS NIH HHS R01 NS064259NINDS NIH HHS R01 NS087726
6 · The paper itself

Abstract

All true metazoans modify their RNAs by converting specific adenosine residues to inosine. Because inosine binds to cytosine, it is a biological mimic for guanosine. This subtle change, termed RNA editing, can have diverse effects on various RNA-mediated cellular pathways, including RNA interference, innate immunity, retrotransposon defense and messenger RNA recoding. Because RNA editing can be regulated, it is an ideal tool for increasing genetic diversity, adaptation and environmental acclimation. This review will cover the following themes related to RNA editing: (1) how it is used to modify different cellular RNAs, (2) how frequently it is used by different organisms to recode mRNA, (3) how specific recoding events regulate protein function, (4) how it is used in adaptation and (5) emerging evidence that it can be used for acclimation. Organismal biologists with an interest in adaptation and acclimation, but with little knowledge of RNA editing, are the intended audience.

Indexed as

RNA EditingAcclimatizationAdaptation, PhysiologicalAdenosineAdenosine DeaminaseAnimalsCalcium ChannelsDeaminationImmunity, InnateReceptors, G-Protein-CoupledRNA InterferenceRNA, MessengerAdenosineAdenosine DeaminaseCalcium ChannelsReceptors, G-Protein-CoupledRNA, MessengerAcclimationAdaptationADARRNA modificationsRNA processing

Identifiers

PMID26085659
PMCPMC4487009
OpenAlexW1912692175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.