Evidence map›Paper›PMID 26085647›Full record

ArticleInternational journal of surgical pathology2015

Pericyte Antigens in Perivascular Soft Tissue Tumors.

Jia Shen, Swati Shrestha, Yu-Hsin Yen, Greg Asatrian, Marco Mravic, Chia Soo, Kang Ting, Sarah M Dry, Bruno Peault, Aaron W James

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of surgical pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Blood Vessel Resident Human Stem Cells in Health and Disease.Stem cells translational medicine · 2022
    Review
  3. Sarcoma Tumor Microenvironment.Advances in experimental medicine and biology · 2020
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Pericyte antigens in angiomyolipoma and PEComa family tumors.Medical oncology (Northwood, London, England) · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Jia ShenUniversity of California, Los Angeles, CA, USA.
Swati ShresthaUniversity of California, Los Angeles, CA, USA.
Yu-Hsin YenUniversity of California, Los Angeles, CA, USA.
Greg AsatrianUniversity of California, Los Angeles, CA, USA.
Marco MravicUniversity of California, Los Angeles, CA, USA.
Chia SooUniversity of California, Los Angeles, CA, USA.
Kang TingUniversity of California, Los Angeles, CA, USA.
Sarah M DryUniversity of California, Los Angeles, CA, USA.
Bruno PeaultUniversity of California, Los Angeles, CA, USA University of Edinburgh, Edinburgh, UK.
Aaron W JamesUniversity of California, Los Angeles, CA, USA Awjames@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

MARC U*STAR Program at the University of California, Los AngelesT34GM008563 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCEVOY, MEGAN M, POE, GINA R · 1996 to 2023
$9.7M
Medical Research Council G1000816NIGMS NIH HHS T34 GM008563
6 · The paper itself

Abstract

introductionPerivascular soft tissue tumors are relatively uncommon neoplasms of unclear line of differentiation, although most are presumed to originate from pericytes or modified perivascular cells. Among these, glomus tumor, myopericytoma, and angioleiomyoma share a spectrum of histologic findings and a perivascular growth pattern. In contrast, solitary fibrous tumor (previously termed hemangiopericytoma) was once hypothesized to have pericytic differentiation.

methodsHere, we systematically examine pericyte immunohistochemical markers among glomus tumor (including malignant glomus tumor), myopericytoma, angioleiomyoma, and solitary fibrous tumor. Immunohistochemical staining and semiquantification was performed using well-defined pericyte antigens, including αSMA, CD146, and PDGFRβ.

resultsGlomus tumor and myopericytoma demonstrate diffuse staining for all pericyte markers, including immunohistochemical reactivity for αSMA, CD146, and PDGFRβ. Malignant glomus tumors all showed some degree of pericyte marker immunoreactivity, although it was significantly reduced. Angioleiomyoma shared a similar αSMA + CD146 + PDGFRβ+ immunophenotype; however, this was predominantly seen in the areas of perivascular tumor growth. Solitary fibrous tumors showed patchy PDGFRβ immunoreactivity only. DISCUSSION: In summary, pericyte marker expression is a ubiquitous finding in glomus tumor, myopericytoma, and angioleiomyoma. Malignant glomus tumor shows a comparative reduction in pericyte marker expression, which may represent partial loss of pericytic differentiation. Pericyte markers are essentially not seen in solitary fibrous tumor. The combination of αSMA, CD146, and PDGFRβ immunohistochemical stainings may be of utility for the evaluation of pericytic differentiation in soft tissue tumors.

Indexed as

Antigens, NeoplasmBiomarkers, TumorHumansImmunohistochemistryPericytesRetrospective StudiesSoft Tissue NeoplasmsAntigens, NeoplasmBiomarkers, TumorangioleiomyomaCD146glomus tumorhemangiopericytomaMel-CAMmyopericytomaPDGFRBpericyteplatelet-derived growth factor receptorsolitary fibrous tumor

Identifiers

PMID26085647
PMCPMC4641786
OpenAlexW2223406828

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.