Evidence map›Paper›PMID 26085612›Full record

ArticleJournal of clinical microbiology2015

Morphological and Molecular Characterization of Exophiala polymorpha sp. nov. Isolated from Sporotrichoid Lymphocutaneous Lesions in a Patient with Myasthenia Gravis.

Lee K Yong, Nathan P Wiederhold, Deanna A Sutton, Marcelo Sandoval-Denis, Jonathan R Lindner, Hongxin Fan, Carmita Sanders, Josep Guarro

Abstract readCase Reports
In one paragraph

Article in Journal of clinical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. A novel case of feline Exophiala spinifera disease in Americas: review integrating diagnosis and clinical.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Review
  2. Article
  3. Article
  4. Species Diversity, Distribution, and Phylogeny ofJournal of fungi (Basel, Switzerland) · 2022
    Article
  5. Article
  6. MycoKeys · 2022
    Article
  7. Medical mycology case reports · 2020
    Article
  8. A NovelFrontiers in veterinary science · 2020
    Article
  9. Review
  10. Article
  11. Name Changes for Fungi of Medical Importance, 2012 to 2015.Journal of clinical microbiology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lee K YongInfectious Diseases, P.C., St. Charles, Missouri, USA.
Nathan P WiederholdFungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA wiederholdn@uthscsa.edu.
Deanna A SuttonFungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Marcelo Sandoval-DenisUnitat de Micologia, IISPV, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain.ORCID http://orcid.org/0000-0001-6832-0252
Jonathan R LindnerFungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Hongxin FanFungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Carmita SandersFungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Josep GuarroUnitat de Micologia, IISPV, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exophiala species are capable of causing cutaneous and subcutaneous infections in immunocompromised patients. An Exophiala isolate was cultured from a biopsy specimen of a lesion on the forearm of a patient with myasthenia gravis. The patient also had lesions on the palm and distal aspects of the hand, which were successfully treated with a long-term course of itraconazole. A detailed morphological and molecular characterization of the isolate was undertaken. Phylogenetic analysis of the internal transcribed spacer region and portions of the β-tubulin and translation elongation factor 1-alpha genes indicated that the isolate was a novel species closely related to but genetically distinct from species within the Exophiala spinifera clade; the name Exophiala polymorpha sp. nov. is proposed. Morphologically, E. polymorpha most closely resembles E. xenobiotica but it differs in possessing phialides bearing prominent, wide collarettes, and it does not produce chlamydospores.

Indexed as

AgedAntifungal AgentsBiopsyCluster AnalysisDermatomycosesDNA, FungalDNA, Ribosomal SpacerExophialaFemaleHistocytochemistryHumansItraconazoleMicrobiological TechniquesMicroscopyMolecular Sequence DataMyasthenia GravisAntifungal AgentsDNA, FungalDNA, Ribosomal SpacerItraconazolePeptide Elongation Factor 1Tubulin

Identifiers

PMID26085612
PMCPMC4540895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.