Evidence map›Paper›PMID 26085610›Full record

ArticleJournal of clinical microbiology2015

Fonsecaea pugnacius, a Novel Agent of Disseminated Chromoblastomycosis.

Conceição M P S de Azevedo, Renata R Gomes, Vania A Vicente, Daniel W C L Santos, Sirlei G Marques, Mariana M F do Nascimento, Caroline E W Andrade, Raimunda R Silva, Flávio Queiroz-Telles, G Sybren de Hoog

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Journal of clinical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
  2. IMA fungus · 2025
    Article
  3. Article
  4. Article
  5. Chromoblastomycosis in Brazil: A review of 450 published cases.Revista da Sociedade Brasileira de Medicina Tropical · 2024
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Pathogenicity and Growth Conditions ModulateFrontiers in cellular and infection microbiology · 2022
    Article
  12. Clinical infection in practice · 2022
    Article
  13. Review
  14. Journal of fungi (Basel, Switzerland) · 2020
    Article
  15. Article
  16. Genomics and Virulence ofFrontiers in genetics · 2020
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Conceição M P S de AzevedoDepartment of Medicine, Federal University of Maranhão, Brazil, São Luis, MA, Brazil.
Renata R GomesMicrobiology, Parasitology and Pathology Post-graduation Program, Department of Basic Pathology, Federal University of Paraná, Curitiba, PR, Brazil.
Vania A VicenteMicrobiology, Parasitology and Pathology Post-graduation Program, Department of Basic Pathology, Federal University of Paraná, Curitiba, PR, Brazil vicente@ufpr.br s.hoog@cbs.knaw.nl.
Daniel W C L SantosInstitute of Infectious Diseases Emilio Ribas, São Paulo, SP, Brazil.
Sirlei G MarquesUniversity Hospital of Federal University of Maranhão and Cedro Laboratories Maranhão, São Luis, MA, Brazil.
Mariana M F do NascimentoMicrobiology, Parasitology and Pathology Post-graduation Program, Department of Basic Pathology, Federal University of Paraná, Curitiba, PR, Brazil.
Caroline E W AndradeMicrobiology, Parasitology and Pathology Post-graduation Program, Department of Basic Pathology, Federal University of Paraná, Curitiba, PR, Brazil.
Raimunda R SilvaDepartment of Medicine, Federal University of Maranhão, Brazil, São Luis, MA, Brazil.
Flávio Queiroz-TellesMicrobiology, Parasitology and Pathology Post-graduation Program, Department of Basic Pathology, Federal University of Paraná, Curitiba, PR, Brazil Clinical Hospital of the Federal University of Paraná, Curitiba, PR, Brazil.
G Sybren de HoogMicrobiology, Parasitology and Pathology Post-graduation Program, Department of Basic Pathology, Federal University of Paraná, Curitiba, PR, Brazil Centraalbureau voor Schimmelcultures KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands vicente@ufpr.br s.hoog@cbs.knaw.nl.
Universidade Federal do Paraná · BRUniversidade Federal do Maranhão · BRInstituto de Infectologia Emílio Ribas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a fatal case of a chromoblastomycosis-like infection caused by a novel species of Fonsecaea in a 52-year-old immunocompetent Caucasian male from an area of chromoblastomycosis endemicity in Brazil. The patient had a 30-year history of slowly evolving, verrucous lesions on the right upper arm which gradually affected the entire arm, the left hemifacial area, and the nose. Subsequent dissemination to the brain was observed, which led to death of the patient. The internal transcribed spacer (ITS) and partial large subunit (LSU), BT2, and CDC42 genes of the isolates recovered from skin and brain were sequenced, confirming the novelty of the species. The species is clinically unique in causing brain abscesses secondary to chromoblastomycosis lesions despite the apparent intact immunity of the patient. Histopathologic appearances were very different, showing muriform cells in skin and hyphae in brain.

Indexed as

AscomycotaBrainBrazilChromoblastomycosisCluster AnalysisDNA, FungalDNA, RibosomalDNA, Ribosomal SpacerFatal OutcomeHeadHistocytochemistryHumansMagnetic Resonance ImagingMaleMicroscopyMiddle AgedDNA, FungalDNA, RibosomalDNA, Ribosomal SpacerRNA, RibosomalRNA, ribosomal, 26S

Identifiers

PMID26085610
PMCPMC4508443
OpenAlexW1852763708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.